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Protein Ontology report - tyrosine-protein kinase BTK
PR:000002110 - http://purl.obolibrary.org/obo/PR_000002110
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002110   
  PRO nametyrosine-protein kinase BTK 
  Synonyms
PRO-Short-label: EXACT:BTK
Gene-based: RELATED:AGMX1 | ATK | BPK
Other: EXACT:agammaglobulinaemia tyrosine kinase | agammaglobulinemia tyrosine kinase | B-cell progenitor kinase | bruton tyrosine kinase | kinase EMB
  Definition"A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000001967 TEC-type tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500765;IUPHARobj:1948
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000002110

tyrosine-protein kinase BTK

BTK


"A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P35991

tyrosine-protein kinase BTK (mouse)

mBTK


"A tyrosine-protein kinase BTK that is encoded in the genome of mouse." [OMA:P35991, PRO:WCB]


Yes
organism-sequence



PR:P35991-1

tyrosine-protein kinase BTK isoform 1 (mouse)

mBTK/iso:1


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000037482

tyrosine-protein kinase BTK phosphorylated 1 (mouse)

mBTK/Phos:1


"A tyrosine-protein kinase BTK (mouse) that is phosphorylated on two Tyr residues. Site 1 is a Tyr within the Src homology type 1 (SH1) domain and is transphosphorylated by a Src family tyrosine kinase. Site 2 is an autophosphorylation site within the Btk SH3 domain. UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048." [PMID:9326643]


organism-gene



PR:Q06187

tyrosine-protein kinase BTK (human)

hBTK


"A tyrosine-protein kinase BTK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06187]


organism-sequence



PR:Q06187-1

tyrosine-protein kinase BTK isoform BTK-A (human)

hBTK/iso:BTK-A


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q06187-2

tyrosine-protein kinase BTK isoform BTK-C (human)

hBTK/iso:BTK-C


"A tyrosine-protein kinase BTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-2." [PRO:DNx, UniProtKB:Q06187]


organism-modification



PR:000044351

tyrosine-protein kinase BTK, initiator methionine removed form (human)

hBTK/InitMet-


"A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]


Yes
organism-modification



PR:000046518

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)

hBTK/InitMet-/Phos:2


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]


organism-modification



PR:000046519

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)

hBTK/InitMet-/Phos:1


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]


organism-modification



PR:000045882

tyrosine-protein kinase BTK phosphorylated 1 (human)

hBTK/Phos:1


"A tyrosine-protein kinase BTK (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Tyr-551, MOD:00048." [iPTMnet:Q06187, PMID:11226282, PMID:7565679]


organism-modification



PR:000069637

tyrosine-protein kinase BTK deaminated 1 (human)

hBTK/Deam:1


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Gln-103 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Gln-103, MOD:00685." [IEDB_epitope:1353605, PRO:DNx]


organism-modification



PR:000070839

tyrosine-protein kinase BTK deaminated 2 (human)

hBTK/Deam:2


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Asn-381 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Asn-381, MOD:00684." [IEDB_epitope:1376974, PRO:DNx]


organism-modification



PR:000077962

tyrosine-protein kinase BTK methylated 1 (human)

hBTK/Me:1


"A tyrosine-protein kinase BTK (human) that has been methylated on the residue at the position equivalent to Cys-145 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Cys-145, MOD:00660." [IEDB_epitope:1018627, PRO:DNx]


sequence



PR:000002236

tyrosine-protein kinase BTK isoform 1

BTK/iso:1


"A tyrosine-protein kinase BTK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P35991-1

tyrosine-protein kinase BTK isoform 1 (mouse)

mBTK/iso:1


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:Q06187-1

tyrosine-protein kinase BTK isoform BTK-A (human)

hBTK/iso:BTK-A


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000026589

tyrosine-protein kinase BTK isoform 1, initiator methionine removed form

BTK/iso:1/InitMet-


"A tyrosine-protein kinase BTK isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018724

tyrosine-protein kinase BTK, initiator methionine removed form

BTK/InitMet-


"A tyrosine-protein kinase BTK that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026589

tyrosine-protein kinase BTK isoform 1, initiator methionine removed form

BTK/iso:1/InitMet-


"A tyrosine-protein kinase BTK isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000044351

tyrosine-protein kinase BTK, initiator methionine removed form (human)

hBTK/InitMet-


"A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]


Yes
organism-modification



PR:000046518

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)

hBTK/InitMet-/Phos:2


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]


organism-modification



PR:000046519

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)

hBTK/InitMet-/Phos:1


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]


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BTK forms found in complexes   

BTK Component
Complexes
PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P35991 mBTK PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)