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Protein Ontology report - TNF receptor-associated factor
PR:000002191 - http://purl.obolibrary.org/obo/PR_000002191
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002191   
  PRO nameTNF receptor-associated factor 
  Synonyms
Other: EXACT:TRAF
  Definition"A protein that is a translation product of a family of genes including the six human genes, TRAF1 to TRAF6. The core architectures of this protein consists of a zinc finger C3HC4 type (Ring finger) (Pfam:PF00097), a TRAF-type zinc finger (Pfam:PF02176) and a MATH domain (Pfam:PF00917)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 16                                        
         Sequence10                                                  Organism-Sequence 22                                        
         Modification6                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF015614
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000002191 TNF receptor-associated factor
AKT1

gene


PR:000002287 TNF receptor-associated factor 1
TRAF1

organism-gene


PR:P39428 TNF receptor-associated factor 1 (mouse)
mTRAF1

organism-sequence


PR:P39428-1 TNF receptor-associated factor 1 isoform 1 (mouse)
mTRAF1/iso:1

organism-gene


PR:Q13077 TNF receptor-associated factor 1 (human)
hTRAF1

organism-sequence


PR:Q13077-1 TNF receptor-associated factor 1 isoform 1 (human)
hTRAF1/iso:1

organism-sequence


PR:Q13077-2 TNF receptor-associated factor 1 isoform h2 (human)
hTRAF1/iso:h2

organism-modification


PR:000066472 TNF receptor-associated factor 1 methylated 1 (human)
hTRAF1/Me:1

organism-modification


PR:000070945 TNF receptor-associated factor 1 methylated 2 (human)
hTRAF1/Me:2

organism-modification


PR:000071340 TNF receptor-associated factor 1 methylated 3 (human)
hTRAF1/Me:3

organism-modification


PR:000075922 TNF receptor-associated factor 1 cysteinylated 1 (human)
hTRAF1/Cyst:1

organism-modification


PR:000079290 TNF receptor-associated factor 1 cysteinylated 2 (human)
hTRAF1/Cyst:2

organism-modification


PR:000080281 TNF receptor-associated factor 1 phosphorylated 1 (human)
hTRAF1/Phos:1

organism-modification


PR:000081420 TNF receptor-associated factor 1 methylated 4 (human)
hTRAF1/Me:4

organism-modification


PR:000081789 TNF receptor-associated factor 1 methylated 5 (human)
hTRAF1/Me:5

sequence


PR:000002373 TNF receptor-associated factor 1 isoform 1
TRAF1/iso:1

organism-sequence


PR:P39428-1 TNF receptor-associated factor 1 isoform 1 (mouse)
mTRAF1/iso:1

organism-sequence


PR:Q13077-1 TNF receptor-associated factor 1 isoform 1 (human)
hTRAF1/iso:1

gene


PR:000002288 TNF receptor-associated factor 2
TRAF2

organism-gene


PR:P39429 TNF receptor-associated factor 2 (mouse)
mTRAF2

organism-sequence


PR:P39429-1 TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1

organism-sequence


PR:P39429-2 TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2

organism-gene


PR:Q12933 TNF receptor-associated factor 2 (human)
hTRAF2

organism-sequence


PR:Q12933-1 TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1

organism-sequence


PR:Q12933-2 TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2

organism-sequence


PR:Q12933-3 TNF receptor-associated factor 2 isoform h3 (human)
hTRAF2/iso:h3

organism-sequence


PR:Q12933-4 TNF receptor-associated factor 2 isoform h4 (human)
hTRAF2/iso:h4

organism-modification


PR:000028382 TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-

Yes
organism-modification


PR:000049534 TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+

organism-modification


PR:000045896 TNF receptor-associated factor 2 phosphorylated 1 (human)
hTRAF2/Phos:1

organism-modification


PR:000069067 TNF receptor-associated factor 2 cysteinylated 1 (human)
hTRAF2/Cyst:1

organism-modification


PR:000079608 TNF receptor-associated factor 2 methylated 1 (human)
hTRAF2/Me:1

sequence


PR:000002374 TNF receptor-associated factor 2 isoform 1
TRAF2/iso:1

organism-sequence


PR:P39429-1 TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1

organism-sequence


PR:Q12933-1 TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1

modification


PR:000026641 TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-

sequence


PR:000002375 TNF receptor-associated factor 2 isoform 2
TRAF2/iso:2

organism-sequence


PR:P39429-2 TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2

sequence


PR:000002376 TNF receptor-associated factor 2 isoform 3
TRAF2/iso:3

organism-sequence


PR:Q12933-2 TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2

modification


PR:000018757 TNF receptor-associated factor 2, initiator methionine removed form
TRAF2/InitMet-

modification


PR:000026641 TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-

organism-modification


PR:000028382 TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-

Yes
organism-modification


PR:000049534 TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+

gene


PR:000002289 TNF receptor-associated factor 3
TRAF3

organism-gene


PR:Q13114 TNF receptor-associated factor 3 (human)
hTRAF3

Yes
organism-sequence


PR:Q13114-1 TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1

organism-sequence


PR:Q13114-2 TNF receptor-associated factor 3 isoform h2 (human)
hTRAF3/iso:h2

organism-modification


PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+

Yes
organism-modification


PR:000064750 TNF receptor-associated factor 3 ubiquitinated form (human)
hTRAF3/UbiqLys+

organism-modification


PR:000069328 TNF receptor-associated factor 3 cysteinylated 1 (human)
hTRAF3/Cyst:1

organism-modification


PR:000083316 TNF receptor-associated factor 3 deaminated 1 (human)
hTRAF3/Deam:1

organism-gene


PR:Q54FC5 TNF receptor-associated factor family protein DDB_G0290965 (Dictyostelium discoideum)
Dicty-TRAF3

organism-gene


PR:Q60803 TNF receptor-associated factor 3 (mouse)
mTRAF3

Yes
organism-sequence


PR:Q60803-1 TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1

sequence


PR:000002377 TNF receptor-associated factor 3 isoform 1
TRAF3/iso:1

organism-sequence


PR:Q13114-1 TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1

organism-sequence


PR:Q60803-1 TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1

modification


PR:000036031 TNF receptor-associated factor 3 K63-polyubiquitinated form
TRAF3/K63polyUbiqLys+

organism-modification


PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+

Yes
gene


PR:000002290 TNF receptor-associated factor 4
TRAF4

organism-gene


PR:G5EG80 F45G2.6 (worm)
TRAF4 (worm)

organism-gene


PR:Q61382 TNF receptor-associated factor 4 (mouse)
mTRAF4

organism-sequence


PR:Q61382-1 TNF receptor-associated factor 4 isoform 1 (mouse)
mTRAF4/iso:1

organism-gene


PR:Q9BUZ4 TNF receptor-associated factor 4 (human)
hTRAF4

organism-sequence


PR:Q9BUZ4-1 TNF receptor-associated factor 4 isoform 1 (human)
hTRAF4/iso:1

organism-sequence


PR:Q9BUZ4-2 TNF receptor-associated factor 4 isoform 2 (human)
hTRAF4/iso:2

organism-modification


PR:000046044 TNF receptor-associated factor 4 phosphorylated 1 (human)
hTRAF4/Phos:1

organism-modification


PR:000068768 TNF receptor-associated factor 4 cysteinylated 1 (human)
hTRAF4/Cyst:1

sequence


PR:000002378 TNF receptor-associated factor 4 isoform 1
TRAF4/iso:1

organism-sequence


PR:Q61382-1 TNF receptor-associated factor 4 isoform 1 (mouse)
mTRAF4/iso:1

organism-sequence


PR:Q9BUZ4-1 TNF receptor-associated factor 4 isoform 1 (human)
hTRAF4/iso:1

sequence


PR:000002379 TNF receptor-associated factor 4 isoform 2
TRAF4/iso:2

organism-sequence


PR:Q9BUZ4-2 TNF receptor-associated factor 4 isoform 2 (human)
hTRAF4/iso:2

gene


PR:000002291 TNF receptor-associated factor 5
TRAF5

organism-gene


PR:O00463 TNF receptor-associated factor 5 (human)
hTRAF5

organism-sequence


PR:O00463-1 TNF receptor-associated factor 5 isoform 1 (human)
hTRAF5/iso:1

organism-sequence


PR:O00463-2 TNF receptor-associated factor 5 isoform h2 (human)
hTRAF5/iso:h2

organism-sequence


PR:O00463-3 TNF receptor-associated factor 5 isoform h3 (human)
hTRAF5/iso:h3

organism-modification


PR:000069096 TNF receptor-associated factor 5 phosphorylated 1 (human)
hTRAF5/Phos:1

organism-gene


PR:P70191 TNF receptor-associated factor 5 (mouse)
mTRAF5

organism-sequence


PR:P70191-1 TNF receptor-associated factor 5 isoform 1 (mouse)
mTRAF5/iso:1

sequence


PR:000002380 TNF receptor-associated factor 5 isoform 1
TRAF5/iso:1

organism-sequence


PR:O00463-1 TNF receptor-associated factor 5 isoform 1 (human)
hTRAF5/iso:1

organism-sequence


PR:P70191-1 TNF receptor-associated factor 5 isoform 1 (mouse)
mTRAF5/iso:1

gene


PR:000002292 TNF receptor-associated factor 6
TRAF6

organism-gene


PR:B5DF45 TNF receptor-associated factor 6 (rat)
rTRAF6

organism-gene


PR:P70196 TNF receptor-associated factor 6 (mouse)
mTRAF6

Yes
organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2

organism-gene


PR:Q6IWL4 TNF receptor-associated factor 6 (zebrafish)
z-TRAF6

organism-gene


PR:Q9Y4K3 TNF receptor-associated factor 6 (human)
hTRAF6

Yes
organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
Yes
Yes
organism-modification


PR:000064696 TNF receptor-associated factor 6 ubiquitinated form (human)
hTRAF6/UbiqLys+

organism-modification


PR:000066371 TNF receptor-associated factor 6 cysteinylated 1 (human)
hTRAF6/Cyst:1

sequence


PR:000002381 TNF receptor-associated factor 6 isoform 1
TRAF6/iso:1

organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1

modification


PR:000003138 TNF receptor-associated factor 6 isoform 1 ubiquitinated form
TRAF6/iso:1/UbiqLys+

modification


PR:000003139 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
TRAF6/iso:1/K63polyUbiq:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

sequence


PR:000002382 TNF receptor-associated factor 6 isoform 2
TRAF6/iso:2

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2

modification


PR:000035713 TNF receptor-associated factor 6 K63-polyubiquitinated 1
TRAF6/K63polyUbiq:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
Yes
Yes
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AKT1 forms found in complexes   

AKT1 Component
 Complexes
PR:000028382 hTRAF2/InitMet- PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:P70196 mTRAF6 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q13114 hTRAF3 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q60803 mTRAF3 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714 hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894