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Protein Ontology report - TNF receptor-associated factor
PR:000002191 - http://purl.obolibrary.org/obo/PR_000002191
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002191   
  PRO nameTNF receptor-associated factor 
  Synonyms
Other: EXACT:TRAF
  Definition"A protein that is a translation product of a family of genes including the six human genes, TRAF1 to TRAF6. The core architectures of this protein consists of a zinc finger C3HC4 type (Ring finger) (Pfam:PF00097), a TRAF-type zinc finger (Pfam:PF02176) and a MATH domain (Pfam:PF00917)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 16                                        
         Sequence10                                                  Organism-Sequence 22                                        
         Modification6                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF015614
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
family


PR:000002191
TNF receptor-associated factor
AKT1
"A protein that is a translation product of a family of genes including the six human genes, TRAF1 to TRAF6. The core architectures of this protein consists of a zinc finger C3HC4 type (Ring finger) (Pfam:PF00097), a TRAF-type zinc finger (Pfam:PF02176) and a MATH domain (Pfam:PF00917)." [PRO:WCB]

gene


PR:000002287
TNF receptor-associated factor 1
TRAF1
"A TNF receptor-associated factor that is a translation product of the human TRAF1 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:P39428
TNF receptor-associated factor 1 (mouse)
mTRAF1
"A TNF receptor-associated factor 1 that is encoded in the genome of mouse." [OMA:P39428, PRO:DNx]

organism-sequence


PR:P39428-1
TNF receptor-associated factor 1 isoform 1 (mouse)
mTRAF1/iso:1
"A TNF receptor-associated factor 1 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q13077
TNF receptor-associated factor 1 (human)
hTRAF1
"A TNF receptor-associated factor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q13077]

organism-sequence


PR:Q13077-1
TNF receptor-associated factor 1 isoform 1 (human)
hTRAF1/iso:1
"A TNF receptor-associated factor 1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q13077-2
TNF receptor-associated factor 1 isoform h2 (human)
hTRAF1/iso:h2
"A TNF receptor-associated factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13077-2." [PRO:DNx, UniProtKB:Q13077]

organism-modification


PR:000066472
TNF receptor-associated factor 1 methylated 1 (human)
hTRAF1/Me:1
"A TNF receptor-associated factor 1 (human) that has been methylated on the residue at the position equivalent to Cys-285 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-285, MOD:00660." [IEDB_epitope:1017680, IEDB_epitope:1017681, IEDB_epitope:1047321, PRO:DNx]

organism-modification


PR:000070945
TNF receptor-associated factor 1 methylated 2 (human)
hTRAF1/Me:2
"A TNF receptor-associated factor 1 (human) that has been methylated on the residue at the position equivalent to Cys-306 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-306, MOD:00660." [IEDB_epitope:1000071, PRO:DNx]

organism-modification


PR:000071340
TNF receptor-associated factor 1 methylated 3 (human)
hTRAF1/Me:3
"A TNF receptor-associated factor 1 (human) that has been methylated on the residue at the position equivalent to Cys-27 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-27, MOD:00660." [IEDB_epitope:1004186, PRO:DNx]

organism-modification


PR:000075922
TNF receptor-associated factor 1 cysteinylated 1 (human)
hTRAF1/Cyst:1
"A TNF receptor-associated factor 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-306 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-306, MOD:00765." [IEDB_epitope:1000070, PRO:DNx]

organism-modification


PR:000079290
TNF receptor-associated factor 1 cysteinylated 2 (human)
hTRAF1/Cyst:2
"A TNF receptor-associated factor 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-22 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-22, MOD:00765." [IEDB_epitope:1035113, IEDB_epitope:631210, PRO:DNx]

organism-modification


PR:000080281
TNF receptor-associated factor 1 phosphorylated 1 (human)
hTRAF1/Phos:1
"A TNF receptor-associated factor 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-25 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Thr-25, MOD:00047." [IEDB_epitope:631211, PRO:DNx]

organism-modification


PR:000081420
TNF receptor-associated factor 1 methylated 4 (human)
hTRAF1/Me:4
"A TNF receptor-associated factor 1 (human) that has been methylated on the residue at the position equivalent to Cys-384 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-384, MOD:00660." [IEDB_epitope:1002353, IEDB_epitope:1048889, PRO:DNx]

organism-modification


PR:000081789
TNF receptor-associated factor 1 methylated 5 (human)
hTRAF1/Me:5
"A TNF receptor-associated factor 1 (human) that has been methylated on the residue at the position equivalent to Cys-22 of the amino acid sequence represented by UniProtKB:Q13077-1. Example: UniProtKB:Q13077-1, Cys-22, MOD:00660." [IEDB_epitope:1035114, PRO:DNx]

sequence


PR:000002373
TNF receptor-associated factor 1 isoform 1
TRAF1/iso:1
"A TNF receptor-associated factor 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13077-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P39428-1
TNF receptor-associated factor 1 isoform 1 (mouse)
mTRAF1/iso:1
"A TNF receptor-associated factor 1 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:Q13077-1
TNF receptor-associated factor 1 isoform 1 (human)
hTRAF1/iso:1
"A TNF receptor-associated factor 1 isoform 1 that is encoded in the genome of human." [PRO:JAN]

gene


PR:000002288
TNF receptor-associated factor 2
TRAF2
"A TNF receptor-associated factor that is a translation product of the human TRAF2 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:P39429
TNF receptor-associated factor 2 (mouse)
mTRAF2
"A TNF receptor-associated factor 2 that is encoded in the genome of mouse." [OMA:P39429, PRO:DNx]

organism-sequence


PR:P39429-1
TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:P39429-2
TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q12933
TNF receptor-associated factor 2 (human)
hTRAF2
"A TNF receptor-associated factor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q12933]

organism-sequence


PR:Q12933-1
TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q12933-2
TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 3 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q12933-3
TNF receptor-associated factor 2 isoform h3 (human)
hTRAF2/iso:h3
"A TNF receptor-associated factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-3." [PRO:DNx, UniProtKB:Q12933]

organism-sequence


PR:Q12933-4
TNF receptor-associated factor 2 isoform h4 (human)
hTRAF2/iso:h4
"A TNF receptor-associated factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-4." [PRO:DNx, UniProtKB:Q12933]

organism-modification


PR:000028382
TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-
"A TNF receptor-associated factor 2, initiator methionine removed form in human. Example: UniProtKB:Q12933-1, 2-501." [PRO:DNx]

Yes
organism-modification


PR:000049534
TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+
"A TNF receptor-associated factor 2, initiator methionine removed form (human) that includes at least one ubiquitinated lysine. UniProtKB:Q12933, 2-501, MOD:01148." [PRO:DNx, Reactome:R-HSA-8862194]

organism-modification


PR:000045896
TNF receptor-associated factor 2 phosphorylated 1 (human)
hTRAF2/Phos:1
"A TNF receptor-associated factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-55 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Ser-55, MOD:00046." [iPTMnet:Q12933, PMID:19336568]

organism-modification


PR:000069067
TNF receptor-associated factor 2 cysteinylated 1 (human)
hTRAF2/Cyst:1
"A TNF receptor-associated factor 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-34 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Cys-34, MOD:00765." [IEDB_epitope:1577094, PRO:DNx]

organism-modification


PR:000079608
TNF receptor-associated factor 2 methylated 1 (human)
hTRAF2/Me:1
"A TNF receptor-associated factor 2 (human) that has been methylated on the residue at the position equivalent to Cys-182 of the amino acid sequence represented by UniProtKB:Q12933-1. Example: UniProtKB:Q12933-1, Cys-182, MOD:00660." [IEDB_epitope:999579, PRO:DNx]

sequence


PR:000002374
TNF receptor-associated factor 2 isoform 1
TRAF2/iso:1
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P39429-1
TNF receptor-associated factor 2 isoform 1 (mouse)
mTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:Q12933-1
TNF receptor-associated factor 2 isoform 1 (human)
hTRAF2/iso:1
"A TNF receptor-associated factor 2 isoform 1 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000026641
TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-
"A TNF receptor-associated factor 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

sequence


PR:000002375
TNF receptor-associated factor 2 isoform 2
TRAF2/iso:2
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39429-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P39429-2
TNF receptor-associated factor 2 isoform 2 (mouse)
mTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

sequence


PR:000002376
TNF receptor-associated factor 2 isoform 3
TRAF2/iso:3
"A TNF receptor-associated factor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12933-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q12933-2
TNF receptor-associated factor 2 isoform 2 (human)
hTRAF2/iso:2
"A TNF receptor-associated factor 2 isoform 3 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000018757
TNF receptor-associated factor 2, initiator methionine removed form
TRAF2/InitMet-
"A TNF receptor-associated factor 2 that has had the initiator methionine removed." [PRO:DNx]

modification


PR:000026641
TNF receptor-associated factor 2 isoform 1, initiator methionine removed form
TRAF2/iso:1/InitMet-
"A TNF receptor-associated factor 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000028382
TNF receptor-associated factor 2, initiator methionine removed form (human)
hTRAF2/InitMet-
"A TNF receptor-associated factor 2, initiator methionine removed form in human. Example: UniProtKB:Q12933-1, 2-501." [PRO:DNx]

Yes
organism-modification


PR:000049534
TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human)
hTRAF2/InitMet-/UbiqLys+
"A TNF receptor-associated factor 2, initiator methionine removed form (human) that includes at least one ubiquitinated lysine. UniProtKB:Q12933, 2-501, MOD:01148." [PRO:DNx, Reactome:R-HSA-8862194]

gene


PR:000002289
TNF receptor-associated factor 3
TRAF3
"A TNF receptor-associated factor that is a translation product of the human TRAF3 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:Q13114
TNF receptor-associated factor 3 (human)
hTRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of human." [PRO:CNA]

Yes
organism-sequence


PR:Q13114-1
TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q13114-2
TNF receptor-associated factor 3 isoform h2 (human)
hTRAF3/iso:h2
"A TNF receptor-associated factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13114-2." [PRO:DNx, UniProtKB:Q13114]

organism-modification


PR:000036032
TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+
"A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772." [Reactome:R-HSA-936402]

Yes
organism-modification


PR:000064750
TNF receptor-associated factor 3 ubiquitinated form (human)
hTRAF3/UbiqLys+
"A TNF receptor-associated factor 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q13114, MOD:01148." [PRO:DNx, Reactome:R-HSA-936556]

organism-modification


PR:000069328
TNF receptor-associated factor 3 cysteinylated 1 (human)
hTRAF3/Cyst:1
"A TNF receptor-associated factor 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13114-1. Example: UniProtKB:Q13114-1, Cys-117, MOD:00765." [IEDB_epitope:1578434, PRO:DNx]

organism-modification


PR:000083316
TNF receptor-associated factor 3 deaminated 1 (human)
hTRAF3/Deam:1
"A TNF receptor-associated factor 3 (human) that has been deaminated on the residue at the position equivalent to Gln-278 of the amino acid sequence represented by UniProtKB:Q13114-1. Example: UniProtKB:Q13114-1, Gln-278, MOD:00685." [IEDB_epitope:1777217, PRO:DNx]

organism-gene


PR:Q54FC5
TNF receptor-associated factor family protein DDB_G0290965 (Dictyostelium discoideum)
Dicty-TRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54FC5, PRO:DNx]

organism-gene


PR:Q60803
TNF receptor-associated factor 3 (mouse)
mTRAF3
"A TNF receptor-associated factor 3 that is encoded in the genome of mouse." [OMA:Q60803, PRO:CNA]

Yes
organism-sequence


PR:Q60803-1
TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

sequence


PR:000002377
TNF receptor-associated factor 3 isoform 1
TRAF3/iso:1
"A TNF receptor-associated factor 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13114-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q13114-1
TNF receptor-associated factor 3 isoform 1 (human)
hTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q60803-1
TNF receptor-associated factor 3 isoform 1 (mouse)
mTRAF3/iso:1
"A TNF receptor-associated factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

modification


PR:000036031
TNF receptor-associated factor 3 K63-polyubiquitinated form
TRAF3/K63polyUbiqLys+
"A TNF receptor-associated factor 3 that has been cross-linked to K63-linked polyubiquitin. Example: UniProtKB:Q13114, PR:000044772." [PRO:CNA]

organism-modification


PR:000036032
TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
hTRAF3/K63polyUbiq+
"A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772." [Reactome:R-HSA-936402]

Yes
gene


PR:000002290
TNF receptor-associated factor 4
TRAF4
"A TNF receptor-associated factor that is a translation product of the human TRAF4 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:G5EG80
F45G2.6 (worm)
TRAF4 (worm)
"A TNF receptor-associated factor 4 that is encoded in the genome of worm." [PRO:WCB]

organism-gene


PR:Q61382
TNF receptor-associated factor 4 (mouse)
mTRAF4
"A TNF receptor-associated factor 4 that is encoded in the genome of mouse." [OMA:Q61382, PRO:DNx]

organism-sequence


PR:Q61382-1
TNF receptor-associated factor 4 isoform 1 (mouse)
mTRAF4/iso:1
"A TNF receptor-associated factor 4 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q9BUZ4
TNF receptor-associated factor 4 (human)
hTRAF4
"A TNF receptor-associated factor 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9BUZ4]

organism-sequence


PR:Q9BUZ4-1
TNF receptor-associated factor 4 isoform 1 (human)
hTRAF4/iso:1
"A TNF receptor-associated factor 4 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:Q9BUZ4-2
TNF receptor-associated factor 4 isoform 2 (human)
hTRAF4/iso:2
"A TNF receptor-associated factor 4 isoform 2 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000046044
TNF receptor-associated factor 4 phosphorylated 1 (human)
hTRAF4/Phos:1
"A TNF receptor-associated factor 4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-426 of the amino acid sequence represented by UniProtKB:Q9BUZ4-1. Example: UniProtKB:Q9BUZ4-1, Ser-426, MOD:00046." [iPTMnet:Q9BUZ4, PMID:22547678]

organism-modification


PR:000068768
TNF receptor-associated factor 4 cysteinylated 1 (human)
hTRAF4/Cyst:1
"A TNF receptor-associated factor 4 (human) that has been cysteinylated on the residue at the position equivalent to Cys-332 of the amino acid sequence represented by UniProtKB:Q9BUZ4-1. Example: UniProtKB:Q9BUZ4-1, Cys-332, MOD:00765." [IEDB_epitope:927373, PRO:DNx]

sequence


PR:000002378
TNF receptor-associated factor 4 isoform 1
TRAF4/iso:1
"A TNF receptor-associated factor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BUZ4-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q61382-1
TNF receptor-associated factor 4 isoform 1 (mouse)
mTRAF4/iso:1
"A TNF receptor-associated factor 4 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-sequence


PR:Q9BUZ4-1
TNF receptor-associated factor 4 isoform 1 (human)
hTRAF4/iso:1
"A TNF receptor-associated factor 4 isoform 1 that is encoded in the genome of human." [PRO:JAN]

sequence


PR:000002379
TNF receptor-associated factor 4 isoform 2
TRAF4/iso:2
"A TNF receptor-associated factor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BUZ4-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q9BUZ4-2
TNF receptor-associated factor 4 isoform 2 (human)
hTRAF4/iso:2
"A TNF receptor-associated factor 4 isoform 2 that is encoded in the genome of human." [PRO:JAN]

gene


PR:000002291
TNF receptor-associated factor 5
TRAF5
"A TNF receptor-associated factor that is a translation product of the human TRAF5 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:O00463
TNF receptor-associated factor 5 (human)
hTRAF5
"A TNF receptor-associated factor 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O00463]

organism-sequence


PR:O00463-1
TNF receptor-associated factor 5 isoform 1 (human)
hTRAF5/iso:1
"A TNF receptor-associated factor 5 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:O00463-2
TNF receptor-associated factor 5 isoform h2 (human)
hTRAF5/iso:h2
"A TNF receptor-associated factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00463-2." [PRO:DNx, UniProtKB:O00463]

organism-sequence


PR:O00463-3
TNF receptor-associated factor 5 isoform h3 (human)
hTRAF5/iso:h3
"A TNF receptor-associated factor 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00463-3." [PRO:DNx, UniProtKB:O00463]

organism-modification


PR:000069096
TNF receptor-associated factor 5 phosphorylated 1 (human)
hTRAF5/Phos:1
"A TNF receptor-associated factor 5 (human) that has been phosphorylated on the residue at the position equivalent to Ser-270 of the amino acid sequence represented by UniProtKB:O00463-1. Example: UniProtKB:O00463-1, Ser-270, MOD:00046." [IEDB_epitope:2146030, PRO:DNx]

organism-gene


PR:P70191
TNF receptor-associated factor 5 (mouse)
mTRAF5
"A TNF receptor-associated factor 5 that is encoded in the genome of mouse." [OMA:P70191, PRO:DNx]

organism-sequence


PR:P70191-1
TNF receptor-associated factor 5 isoform 1 (mouse)
mTRAF5/iso:1
"A TNF receptor-associated factor 5 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

sequence


PR:000002380
TNF receptor-associated factor 5 isoform 1
TRAF5/iso:1
"A TNF receptor-associated factor 5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00463-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:O00463-1
TNF receptor-associated factor 5 isoform 1 (human)
hTRAF5/iso:1
"A TNF receptor-associated factor 5 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-sequence


PR:P70191-1
TNF receptor-associated factor 5 isoform 1 (mouse)
mTRAF5/iso:1
"A TNF receptor-associated factor 5 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

gene


PR:000002292
TNF receptor-associated factor 6
TRAF6
"A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:B5DF45
TNF receptor-associated factor 6 (rat)
rTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of rat." [OMA:B5DF45, PRO:DNx]

organism-gene


PR:P70196
TNF receptor-associated factor 6 (mouse)
mTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of mouse." [OMA:P70196, PRO:CNA]

Yes
organism-sequence


PR:P70196-1
TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-sequence


PR:P70196-2
TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2
"A TNF receptor-associated factor 6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q6IWL4
TNF receptor-associated factor 6 (zebrafish)
z-TRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of zebrafish." [OMA:Q6IWL4, PRO:DNx]

organism-gene


PR:Q9Y4K3
TNF receptor-associated factor 6 (human)
hTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9Y4K3]

Yes
organism-sequence


PR:Q9Y4K3-1
TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
Yes
Yes
organism-modification


PR:000064696
TNF receptor-associated factor 6 ubiquitinated form (human)
hTRAF6/UbiqLys+
"A TNF receptor-associated factor 6 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q9Y4K3, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782845, Reactome:R-HSA-6783233]

organism-modification


PR:000066371
TNF receptor-associated factor 6 cysteinylated 1 (human)
hTRAF6/Cyst:1
"A TNF receptor-associated factor 6 (human) that has been cysteinylated on the residue at the position equivalent to Cys-390 of the amino acid sequence represented by UniProtKB:Q9Y4K3. UniProtKB:Q9Y4K3, Cys-390, MOD:00765." [IEDB_epitope:1004109, PRO:DNx]

sequence


PR:000002381
TNF receptor-associated factor 6 isoform 1
TRAF6/iso:1
"A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4K3-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P70196-1
TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-sequence


PR:Q9Y4K3-1
TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000003138
TNF receptor-associated factor 6 isoform 1 ubiquitinated form
TRAF6/iso:1/UbiqLys+
"A TNF receptor-associated factor 6 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000003139
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
TRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 ubiquitinated form that is a major product of site-specific Lys-63-linked auto-ubiquitination. The ubiquitinated Lys residue is located downstream the RING domain. Example: UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

sequence


PR:000002382
TNF receptor-associated factor 6 isoform 2
TRAF6/iso:2
"A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70196-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P70196-2
TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2
"A TNF receptor-associated factor 6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

modification


PR:000035713
TNF receptor-associated factor 6 K63-polyubiquitinated 1
TRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 that is a major product of site-specific Lys-63-linked auto-ubiquitination. Example: UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:CNx, PRO:DAN]

organism-modification


PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
Yes
Yes
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AKT1 forms found in complexes   

AKT1 Component
 Complexes
PR:000028382 hTRAF2/InitMet- PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:P70196 mTRAF6 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q13114 hTRAF3 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q60803 mTRAF3 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714 hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894