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Protein Ontology report - NS12345
PR:000036838 - http://purl.obolibrary.org/obo/PR_000036838
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036838   
  PRO nameNS12345 
  Synonyms
PRO-Short-label: EXACT:DenV-NS12345
Other: EXACT:Non-structural proteins | Nonstructural proteins | NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5
  Definition"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5." [PMID:1433530, PMID:22022449, PRO:ES] 
  CommentRequested by=IDODEN. 
  PRO Categorymodification 
  ParentPR:000036818 dengue virus genome polyprotein proteolytic cleavage product
PR:000036817 dengue virus genome polyprotein, N-glycosylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification17                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000036838 NS12345
DenV-NS12345

modification


PR:000036826 NS2A-alpha
DenV-NS2Aalpha

modification


PR:000036827 NS2B
DenV-NS2B

Yes
organism-modification


PR:000044761 NS2B (Dengue virus 2 Thailand/NGS-C/1944)
NS2B (DEN2N)
Yes
modification


PR:000036839 NS345
DenV-NS345

modification


PR:000036828 NS3
DenV-NS3

Yes
organism-modification


PR:000044762 NS3 (Dengue virus 2 Thailand/NGS-C/1944)
NS3 (DEN2N)
Yes
modification


PR:000036840 NS4A-NS4B-NS5
DenV-NS4AB5

modification


PR:000036841 NS4AB
DenV-NS4AB

modification


PR:000036830 NS4A
DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944)
NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84)
NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B
DenV-2KNS4B

modification


PR:000036831 2K
DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944)
2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5
DenV-NS4B5

modification


PR:000036873 NS2B-NS3 polyprotein precursor
DenV-NS2B3

modification


PR:000036998 NS1-NS2A
DenV-NS12A

modification


PR:000036824 NS1
DenV-NS1

Yes
modification


PR:000037000 NS1, with complex sugar attached
DenV-NS1/sugar(+)

Yes
modification


PR:000037001 NS1, without complex sugar attached
DenV-NS1/sugar(-)

Yes
organism-modification


PR:000044758 NS1 (Dengue virus 2 Thailand/NGS-C/1944)
NS1 (DEN2N)
Yes
modification


PR:000036825 NS2A
DenV-NS2A

organism-modification


PR:000044759 NS2A (Dengue virus 2 Thailand/NGS-C/1944)
NS2A (DEN2N)
Yes
organism-modification


PR:000044760 NS2A (Dengue virus 2 Thailand/16681/84)
NS2A (DEN26)
Yes
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DenV-NS12345 forms found in complexes   

DenV-NS12345 Component
 Complexes
PR:000036824 DenV-NS1 PR:000037002 NS1 dimer
PR:000036827 DenV-NS2B PR:000036829 NS2B-NS3 complex
PR:000036828 DenV-NS3 PR:000036829 NS2B-NS3 complex
PR:000037000 DenV-NS1/sugar(+) PR:000037003 NS1 dimer, with complex sugar attached
PR:000037005 NS1 hexamer, with complex sugar attached
PR:000037001 DenV-NS1/sugar(-) PR:000037004 NS1 dimer, without complex sugar unattached
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044758 NS1 (DEN2N)
UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160		 acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:23408612
GO:0097281 immune complex formation PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044759 NS2A (DEN2N)
UniProtKB:P14340, 1128-1345		 acts_upstream_of_or_withinGO:0019068 virion assembly PMID:23408612
GO:0019076 viral release from host cell PMID:23408612
GO:0019079 viral genome replication PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044760 NS2A (DEN26)
UniProtKB:P29990, 1128-1345		 acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044761 NS2B (DEN2N)
UniProtKB:P14340, 1346-1475		 acts_upstream_of_or_withinGO:1900005 positive regulation of serine-type endopeptidase activity PMID:10744671
enablescontributes_to GO:0008236 serine-type peptidase activity PMID:10744671
PR:000044762 NS3 (DEN2N)
UniProtKB:P14340, 1476-2093		 acts_upstream_of_or_withinGO:0019082 viral protein processing PMID:10744671
enablesGO:0003724 RNA helicase activity PMID:10744671
GO:0008236 serine-type peptidase activity PMID:10744671
GO:0017111 ribonucleoside triphosphate phosphatase activity PMID:10744671
PR:000044763 NS4A (DEN2N)
UniProtKB:P14340, 2094-2220		 acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:17276984
located_inGO:0019034 viral replication complex PMID:17276984
PR:000044764 NS4A (DEN26)
UniProtKB:P29990, 2094-2220		 acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044765 2K (DEN2N)
UniProtKB:P14340, 2221-2243		 acts_upstream_of_or_withinGO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PMID:17276984
enablesGO:0043495 protein-membrane adaptor activity PMID:21810535
located_inGO:0016020 membrane PMID:21810535