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Protein Ontology report - NS12345
PR:000036838 -
http://purl.obolibrary.org/obo/PR_000036838
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000036838
PRO name
NS12345
Synonyms
PRO-Short-label
:
EXACT:
DenV-NS12345
Other
:
EXACT:
Non-structural proteins | Nonstructural proteins | NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5
Definition
"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5." [
PMID:1433530
,
PMID:22022449
, PRO:ES]
Comment
Requested by=IDODEN.
PRO Category
modification
Parent
PR:000036818
dengue virus genome polyprotein proteolytic cleavage product
PR:000036817
dengue virus genome polyprotein, N-glycosylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
17
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000036838
NS12345, DenV-NS12345
modification
PR:000036826
NS2A-alpha, DenV-NS2Aalpha
modification
PR:000036827
NS2B, DenV-NS2B
Yes
organism-modification
PR:000044761
NS2B (Dengue virus 2 Thailand/NGS-C/1944), NS2B (DEN2N)
Yes
modification
PR:000036839
NS345, DenV-NS345
modification
PR:000036828
NS3, DenV-NS3
Yes
organism-modification
PR:000044762
NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)
Yes
modification
PR:000036840
NS4A-NS4B-NS5, DenV-NS4AB5
modification
PR:000036841
NS4AB, DenV-NS4AB
modification
PR:000036830
NS4A, DenV-NS4A
organism-modification
PR:000044763
NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification
PR:000044764
NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification
PR:000036842
2KNS4B, DenV-2KNS4B
modification
PR:000036831
2K, DenV-2K
organism-modification
PR:000044765
2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification
PR:000036843
NS4B-NS5, DenV-NS4B5
modification
PR:000036873
NS2B-NS3 polyprotein precursor, DenV-NS2B3
modification
PR:000036998
NS1-NS2A, DenV-NS12A
modification
PR:000036824
NS1, DenV-NS1
Yes
modification
PR:000037000
NS1, with complex sugar attached, DenV-NS1/sugar(+)
Yes
modification
PR:000037001
NS1, without complex sugar attached, DenV-NS1/sugar(-)
Yes
organism-modification
PR:000044758
NS1 (Dengue virus 2 Thailand/NGS-C/1944), NS1 (DEN2N)
Yes
modification
PR:000036825
NS2A, DenV-NS2A
organism-modification
PR:000044759
NS2A (Dengue virus 2 Thailand/NGS-C/1944), NS2A (DEN2N)
Yes
organism-modification
PR:000044760
NS2A (Dengue virus 2 Thailand/16681/84), NS2A (DEN26)
Yes
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DenV-NS12345
forms found in complexes
DenV-NS12345
Component
Complexes
PR:000036824
DenV-NS1
PR:000037002
NS1 dimer
PR:000036827
DenV-NS2B
PR:000036829
NS2B-NS3 complex
PR:000036828
DenV-NS3
PR:000036829
NS2B-NS3 complex
PR:000037000
DenV-NS1/sugar(+)
PR:000037003
NS1 dimer, with complex sugar attached
PR:000037005
NS1 hexamer, with complex sugar attached
PR:000037001
DenV-NS1/sugar(-)
PR:000037004
NS1 dimer, without complex sugar unattached
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044758
NS1 (DEN2N)
UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160 | PRO_0000037962, Asn-905/Asn-982, MOD:00160
"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]
acts_upstream_of_or_within
GO:0019079
viral genome replication
PMID:23408612
GO:0097281
immune complex formation
PMID:23408612
located_in
GO:0019034
viral replication complex
PMID:23408612
PR:000044759
NS2A (DEN2N)
UniProtKB:P14340, 1128-1345 | PRO_0000037963
"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]
acts_upstream_of_or_within
GO:0019068
virion assembly
PMID:23408612
GO:0019076
viral release from host cell
PMID:23408612
GO:0019079
viral genome replication
PMID:23408612
located_in
GO:0019034
viral replication complex
PMID:23408612
PR:000044760
NS2A (DEN26)
UniProtKB:P29990, 1128-1345 | PRO_0000037930
"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]
acts_upstream_of_or_within
GO:0060339
negative regulation of type I interferon-mediated signaling pathway
PMID:14612562
PR:000044761
NS2B (DEN2N)
UniProtKB:P14340, 1346-1475 | PRO_0000037964
"An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx]
acts_upstream_of_or_within
GO:1900005
positive regulation of serine-type endopeptidase activity
PMID:10744671
enables
contributes_to
GO:0008236
serine-type peptidase activity
PMID:10744671
PR:000044762
NS3 (DEN2N)
UniProtKB:P14340, 1476-2093 | PRO_0000037965
"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]
acts_upstream_of_or_within
GO:0019082
viral protein processing
PMID:10744671
enables
GO:0003724
RNA helicase activity
PMID:10744671
GO:0008236
serine-type peptidase activity
PMID:10744671
GO:0017111
ribonucleoside triphosphate phosphatase activity
PMID:10744671
PR:000044763
NS4A (DEN2N)
UniProtKB:P14340, 2094-2220 | PRO_0000037966
"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]
acts_upstream_of_or_within
GO:0019079
viral genome replication
PMID:17276984
located_in
GO:0019034
viral replication complex
PMID:17276984
PR:000044764
NS4A (DEN26)
UniProtKB:P29990, 2094-2220 | PRO_0000037933
"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]
acts_upstream_of_or_within
GO:0060339
negative regulation of type I interferon-mediated signaling pathway
PMID:14612562
PR:000044765
2K (DEN2N)
UniProtKB:P14340, 2221-2243 | PRO_0000261391
"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]
acts_upstream_of_or_within
GO:0045051
protein insertion into ER membrane by internal uncleaved signal-anchor sequence
PMID:17276984
enables
GO:0043495
protein-membrane adaptor activity
PMID:21810535
located_in
GO:0016020
membrane
PMID:21810535