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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000004855 - http://purl.obolibrary.org/obo/PR_000004855
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004855   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta 
  Synonyms
PRO-Short-label: EXACT:BUB1B
Gene-based: RELATED:BUBR1 | MAD3L | SSK1
Other: EXACT:BubR1 | MAD3/BUB1-related protein kinase | mitotic checkpoint kinase MAD3L | protein SSK1
  Definition"A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000035665 BUB1/BUB1B protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification6                                                  Organism-Modification 20                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1950
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta, BUB1B

organism-gene


PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human), hBUB1B
Yes
Yes
organism-sequence


PR:O60566-1 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human), hBUB1B/iso:1

organism-modification


PR:000028798 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human), hBUB1B/iso:1/Ac:1

organism-sequence


PR:O60566-2 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human), hBUB1B/iso:h2

organism-sequence


PR:O60566-3 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human), hBUB1B/iso:h3

organism-modification


PR:000035362 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human), hBUB1B/Phos:1
Yes
organism-modification


PR:000035373 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human), hBUB1B/PhosRes-
Yes
Yes
organism-modification


PR:000035428 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human), hBUB1B/Phos:2
Yes
Yes
organism-modification


PR:000035432 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human), hBUB1B/Phos:3
Yes
organism-modification


PR:000035435 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human), hBUB1B/Phos:4
Yes
organism-modification


PR:000065892 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 1 (human), hBUB1B/Me:1

organism-modification


PR:000066223 mitotic checkpoint serine/threonine-protein kinase BUB1 beta cysteinylated 1 (human), hBUB1B/Cyst:1

organism-modification


PR:000070779 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 1 (human), hBUB1B/Deam:1

organism-modification


PR:000074218 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 2 (human), hBUB1B/Deam:2

organism-modification


PR:000074309 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 2 (human), hBUB1B/Me:2

organism-modification


PR:000076756 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 3 (human), hBUB1B/Me:3

organism-modification


PR:000077474 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 4 (human), hBUB1B/Me:4

organism-modification


PR:000077494 mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 3 (human), hBUB1B/Deam:3

organism-modification


PR:000078944 mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 5 (human), hBUB1B/Me:5

organism-modification


PR:000080893 mitotic checkpoint serine/threonine-protein kinase BUB1 beta citrullinated 1 (human), hBUB1B/Cit:1

organism-gene


PR:P41695 checkpoint serine/threonine-protein kinase BUB1 (yeast), yBUB1B
Yes
Yes
organism-gene


PR:Q800D4 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (chicken), chick-BUB1B
Yes
organism-gene


PR:Q8JGT8 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (frog), frog-BUB1B
Yes
Yes
organism-modification


PR:000035425 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog), frog-BUB1B/PhosRes-

organism-modification


PR:000035426 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog), frog-BUB1B/Phos:1
Yes
organism-modification


PR:000035430 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog), frog-BUB1B/Phos:2
Yes
organism-modification


PR:000035433 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog), frog-BUB1B/Phos:3

organism-gene


PR:Q9Z1S0 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (mouse), mBUB1B

sequence


PR:000028795 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1, BUB1B/iso:1

organism-sequence


PR:O60566-1 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human), hBUB1B/iso:1

organism-modification


PR:000028798 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human), hBUB1B/iso:1/Ac:1

modification


PR:000028797 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1, BUB1B/iso:1/Ac:1

organism-modification


PR:000028798 mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human), hBUB1B/iso:1/Ac:1

modification


PR:000035361 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1, BUB1B/Phos:1

organism-modification


PR:000035362 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human), hBUB1B/Phos:1
Yes
organism-modification


PR:000035426 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog), frog-BUB1B/Phos:1
Yes
modification


PR:000035372 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form, BUB1B/PhosRes-

organism-modification


PR:000035373 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human), hBUB1B/PhosRes-
Yes
Yes
organism-modification


PR:000035425 mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog), frog-BUB1B/PhosRes-

modification


PR:000035427 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form, BUB1B/Phos:CDK1+PLK1

organism-modification


PR:000035428 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human), hBUB1B/Phos:2
Yes
Yes
organism-modification


PR:000035430 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog), frog-BUB1B/Phos:2
Yes
modification


PR:000035431 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3, BUB1B/Phos:3

organism-modification


PR:000035432 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human), hBUB1B/Phos:3
Yes
organism-modification


PR:000035433 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog), frog-BUB1B/Phos:3

modification


PR:000035434 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4, BUB1B/Phos:4

organism-modification


PR:000035435 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human), hBUB1B/Phos:4
Yes
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BUB1B forms found in complexes   

BUB1B Component
 Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035563 BUB1B:BUB3 complex (human)
PR:000035575 BUB1B:CDC20 complex (human)
PR:P41695 yBUB1B PR:000035565 BUB1:BUB3 complex (yeast)
PR:Q8JGT8 frog-BUB1B PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035362 hBUB1B/Phos:1
UniProtKB:O60566, Thr-620, MOD:00047 | UniProtKB:O60566-1, Thr-620, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]		 enablesincreased GO:0005515 protein binding with PR:P53350 hPLK1 PMID:17785528
PR:000035373 hBUB1B/PhosRes-

"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0001933 negative regulation of protein phosphorylation PMID:22801780
GO:0010826 negative regulation of centrosome duplication PMID:19503101
GO:0033673 negative regulation of kinase activity PMID:19503101
enablesGO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_inGO:0000776 kinetochore PMID:22801780
GO:0005813 centrosome PMID:19503101
PR:000035426 frog-BUB1B/Phos:1
UniProtKB:Q8JGT8, Thr-605, MOD:00047 | BUBR1 phosphorylated (frog) | xBUBR1 phosphorylated
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER]		 acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
enablesincreased GO:0005515 protein binding with PR:P70032 frog-plk1 PMID:17998400
PR:000035428 hBUB1B/Phos:2
UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047) | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]		 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597
located_inGO:0000776 kinetochore PMID:17785528
PR:000035430 frog-BUB1B/Phos:2
UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER]		 enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17998400
PR:000035432 hBUB1B/Phos:3
UniProtKB:O60566, Thr-608, MOD:00047 | UniProtKB:O60566-1, Thr-608, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]		 acts_upstream_of_or_withindecreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_inGO:0000776 kinetochore PMID:22801780
PR:000035435 hBUB1B/Phos:4
UniProtKB:O60566, Ser-543/Ser-670/Ser-1043, MOD:00046 | UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]		 acts_upstream_of_or_withinincreased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317; PMID:20016069
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
located_inGO:0000776 kinetochore PMID:19015317
PR:O60566 hBUB1B
BUB1B | BUBR1 | MAD3L | SSK1 | hBUBR1 | MAD3/BUB1-related protein kinase (human) | mitotic checkpoint kinase MAD3L (human) | protein SSK1 (human)
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566]		 acts_upstream_of_or_withinGO:0006469 negative regulation of protein kinase activity PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:11030144
GO:0031647 regulation of protein stability PMID:17671183
NOT GO:0034501 protein localization to kinetochore PMID:16760428
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
enablesGO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 BioGRID:BG-682429
GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- BioGRID:BG-682429
GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-682429
GO:0005515 protein binding with PR:O15379 HD3 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-682429
GO:0005515 protein binding with PR:O76070 BCSG1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O95997 EAP1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P04049 cRaf (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P04637-1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-682429
GO:0005515 protein binding with PR:P51587 BRCA2 BioGRID:BG-682429
GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q02224 CENP-E (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13042 ANAPC6 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13547 HD1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92769 HD2 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96GD4 AIK2 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96IF1 AJUBA BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H4B4 CNK BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX3 ANAPC7 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX5 ANAPC4 BioGRID:BG-682429
GO:0016301 kinase activity PMID:11030144
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470; PMID:16760428
GO:0000922 spindle pole PMID:15190214
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804
GO:0005737 cytoplasm PMID:10749118
PR:P41695 yBUB1B
BUB1 | G7542 | YGR188C
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of yeast." [OMA:P41695, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
enablesGO:0005515 protein binding with PR:000035536 UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047 PMID:7969164
GO:0005515 protein binding with PR:P26449 BUB3 PMID:7969164
located_inGO:0000776 kinetochore PMID:22521787
PR:Q800D4 chick-BUB1B
BubR1
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of chicken." [PMID:17276342, PRO:KER]		 located_inGO:0000776 kinetochore PMID:17276342
PR:Q8JGT8 frog-BUB1B
xBUBR1
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of frog." [PMID:12163471, PMID:15241477, PMID:16950116, PRO:KER]		 acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0051310 metaphase chromosome alignment PMID:17709426
enablesGO:0004672 protein kinase activity PMID:12163471
GO:0005515 protein binding with PR:P70039 apc PMID:12163471
GO:0005515 protein binding with PR:P79935 frog-MAD2L1 PMID:12163471
GO:0005515 protein binding with PR:Q6DFD4 fizzy PMID:12163471
GO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:12163471
GO:0005515 protein binding PMID:12163471
located_inGO:0000776 kinetochore PMID:12163471; PMID:17709426
GO:0005694 chromosome PMID:15241477; PMID:16950116