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Protein Ontology Report - TRAF6

PR:000002292 - http://purl.obolibrary.org/obo/PR_000002292
Ontology Information
PRO ID PR:000002292 Show OBO stanza / PAF
PRO name TNF receptor-associated factor 6
Synonyms
PRO-short-label: EXACT: TRAF6
Gene-based: RELATED: RNF85
Other: EXACT: E3 ubiquitin-protein ligase TRAF6 | RING finger protein 85 | RING-type E3 ubiquitin transferase TRAF6 | interleukin-1 signal transducer
Definition A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000002191 TNF receptor-associated factor
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 2 organism-sequence 3
modification 3 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TRAF6 forms found in complexes
TRAF6 Component Complexes
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:P70196 mTRAF6 PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:P70196 mTRAF6 PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:P70196 mTRAF6 PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:P70196 mTRAF6 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:P70196 mTRAF6 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:P70196 mTRAF6 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:P70196 mTRAF6 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:P70196 mTRAF6 PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q9Y4K3 hTRAF6 PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035710
traf6:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:14530355
PR:000035714
hTRAF6/K63polyUbiq:1
Lys-124, PR:000044772 		acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000035715
pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25867
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131
located_in GO:0005829 cytosol Reactome:REACT_23131
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036101
rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26039
PR:000037344
traf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
PR:000028680
traf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25948
PR:000037340
pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0010008 endosome membrane PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25867
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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