Protein Ontology Report - hCDKN1B/iso:1/Phos:2 PR:000025750 - http://purl.obolibrary.org/obo/PR_000025750

Ontology Information
PRO ID	PR:000025750 Show OBO stanza / PAF / GPI
PRO name	cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
Synonyms	PRO-short-label: EXACT: hCDKN1B/iso:1/Phos:2 PRO-proteoform-std: EXACT: UniProtKB:P46527-1, Tyr-88, MOD:00048
Definition	A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 in human. Phosphorylation at this site promotes subsequent Cdk2-mediated phosphorylation at Thr-187. UniProtKB:P46527-1, Tyr-88, MOD:00048. [PMID:17254966, PRO:JAN]
PRO Category	organism-modification
Parent	PR:000025749 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000025750 hCDKN1B/iso:1/Phos:2 Tyr-88, MOD:00048 acts_upstream_of_or_within GO:0051318 G1 phase PMID:17254966 enables GO:0005515 protein binding with PR:P24864 hCCNE1 PMID:17254966 enables GO:0005515 protein binding with PR:P24385 hCCND1 PMID:17254966 enables GO:0005515 protein binding with PR:P20248 hCCNA2 PMID:17254966 enables GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity decreased relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966 enables GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human) PMID:17254966

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