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Protein Ontology Report - hBUB1B/Phos:2

PR:000035428 - http://purl.obolibrary.org/obo/PR_000035428
Ontology Information
PRO ID PR:000035428 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
Synonyms
PRO-short-label: EXACT: hBUB1B/Phos:2
PRO-proteoform-std: NARROW: UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)
Other: RELATED: BUBR1 phosphorylated (human) | hBUBR1 phosphorylated
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Example: UniProtKB:O60566, Thr-620, MOD:00047, (Ser-676, MOD:00046 and/or Thr-680, MOD:00047), (Thr-792, MOD:00047 and/or Thr-1008, MOD:00047). [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]
Comment Kinase=("CDK1"; PR:000003271). Kinase=("PLK1"; PR:P53350).
PRO Category organism-modification
Parent PR:000035427 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1B/Phos:2 forms found in complexes
hBUB1B/Phos:2 Component Complexes
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035428
hBUB1B/Phos:2
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:O43683 hBUB1 PMID:11792804
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:Q15172 hPPP2R5A PMID:23079597
capable_of GO:0004672 protein kinase activity increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
located_in GO:0000776 kinetochore PMID:17785528
participates_in GO:0006974 cellular response to DNA damage stimulus PMID:18440313
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779, PMID:17785528
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0051310 metaphase plate congression PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17376779, PMID:17785528
GO:0006974 cellular response to DNA damage stimulus PR:000035428 hBUB1B/Phos:2

PMID:18440313
GO:0008608 attachment of spindle microtubules to kinetochore PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17785528
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:000035428 hBUB1B/Phos:2

PMID:17785528

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