PRO Entry Report - PR:000037368

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000037368 Show OBO stanza / PAF / GPI

PRO name

pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Synonyms

Other:

EXACT:

activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 (human)

Definition

A pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex whose components are encoded in the genome of human. [PMID:15814722, PMID:16115877, PMID:21737330, PMID:22421964, PRO:VS, Reactome:R-HSA-2562542]

Comment

Requested by=TLR.

PRO Category

organism-complex

Parent

PR:000037367 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037368	PR:Q13546	receptor-interacting serine/threonine-protein kinase 1 (human)	hRIPK1	A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx]	2
	PR:Q14790	caspase-8 (human)	hCASP8	A caspase-8 that is encoded in the genome of human. [PRO:DNx]	2
	PR:Q8IUC6	TIR domain-containing adapter molecule 1 (human)	hTICAM1	A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA]	2
	PR:Q13158	FAS-associated death domain protein (human)	hFADD	A FAS-associated death domain protein that is encoded in the genome of human. [PRO:DNx]	2
	PR:000037305	Toll-like receptor 3, signal peptide removed form (human)	hTLR3/SigPep-	A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]	2
	CHEBI:67208	dsRNA	dsRNA	A double stranded ribonucleic acid. [None]	1

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0010008 endosome membrane	PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

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