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Protein Ontology Report - hCASP8

PR:Q14790 -
This page represents a class of proteins encompassing all the protein products of the CASP8 gene in Homo sapiens.
Ontology Information
PRO ID PR:Q14790 Show OBO stanza / PAF / GPI
PRO name caspase-8 (human)
PRO-short-label: EXACT: hCASP8
Gene-based: RELATED: CASP8 | MCH5
Other: EXACT: CAP4 (human) | CASP-8 (human) | FADD-homologous ICE/ced-3-like protease (human) | FADD-like ICE (human) | FLICE (human) | ICE-like apoptotic protease 5 (human) | MACH (human) | MORT1-associated ced-3 homolog (human) | apoptotic cysteine protease (human) | apoptotic protease Mch-5 (human)
Definition A caspase-8 that is encoded in the genome of human. [PRO:DNx]
PRO Category organism-gene
Parent PR:000002317 caspase-8
Gene Template HGNC:1509 CASP8
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-gene 1
organism-sequence 9
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hCASP8 forms found in complexes
hCASP8 Component Complexes
PR:000036063 hCASP8/iso:1/Clv:1 PR:000036068 caspase-8 complex (human)
PR:000036065 hCASP8/iso:1/Clv:2 PR:000036068 caspase-8 complex (human)
PR:Q14790 hCASP8 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:Q14790 hCASP8 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q14790 hCASP8 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)