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Protein Ontology Report - LPS:CD14

PR:000037465 - http://purl.obolibrary.org/obo/PR_000037465
Ontology Information
PRO ID PR:000037465 Show OBO stanza / PAF
PRO name LPS:CD14 complex
Synonyms
PRO-short-label: EXACT: LPS:CD14
Definition A macromolecular complex that contains CD14 bound to lipopolysaccharides (LPS). [PMID:18761368]
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 4 organism-complex 5
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000029989 PR:000036849 CD14 molecule isoform 1 cleaved and soluble form CD14/iso:1/ClvPrd/soluble A CD14 molecule isoform 1, signal peptide removed form that has been processed by proteolytic cleavage to yield the N-terminal domain lacking a GPI-anchor. [PRO:DAN]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000025493 PR:000002149 CD14 molecule isoform 1 cleaved 2 GPI-anchored form CD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 that is the mature membrane-bound form of this protein. Example: UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [PMID:3385210, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037468 PR:000037470 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (mouse) mCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810-1, 16-336, Asn-336, MOD:00167. [PMID:10601848, PMID:18606699, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000025494 CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037464 PR:000035702 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human) hCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037465 PR:000001889 CD14 molecule CD14 A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. [PRO:WCB]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037466 PR:B0BL87 CD14 molecule (chicken) chick-CD14 A CD14 molecule that is encoded in the genome of chicken. [PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037467 PR:000036850 CD14 molecule isoform 1 cleaved and soluble form (mouse) mCD14/iso:1/ClvPrd/soluble A CD14 molecule isoform 1 cleaved and soluble form in mouse. [PRO:DAN]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000037463 PR:000035703 CD14 molecule isoform 1 cleaved 2 soluble form (human) hCD14/iso:1/Clv:2/soluble A CD14 molecule isoform 1 cleaved 2 soluble form in human. UniProtKB:P08571-1, 20-345. [PRO:DNx, UniProtKB:P08571]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037464
LPS:GPI-anchored CD14 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_in GO:0005886 plasma membrane Reactome:REACT_7856
PR:000037466
LPS:transmembrane CD14 complex (chicken)
acts_upstream_of_or_within GO:0051607 defense response to virus PMID:24034933
acts_upstream_of_or_within GO:0045429 positive regulation of nitric oxide biosynthetic process PMID:24034933
located_in GO:0009986 cell surface PMID:18761368, PMID:24034933
PR:000037463
LPS:secreted CD14 alpha (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_in GO:0005615 extracellular space Reactome:REACT_7856
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:000037466 LPS:transmembrane CD14 complex (chicken)

PMID:18761368, PMID:24034933
GO:0005886 plasma membrane PR:000037464 LPS:GPI-anchored CD14 complex (human)

Reactome:REACT_7856
GO:0005615 extracellular space PR:000037463 LPS:secreted CD14 alpha (human)

Reactome:REACT_7856

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