PRO Entry Report - PR:000037478

Protein Ontology Report - pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)

PR:000037478 - http://purl.obolibrary.org/obo/PR_000037478

Complex Forms Complex Subunits

Ontology Information

PRO ID

PR:000037478 Show OBO stanza / GPI

PRO name

pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)

Synonyms

Other:	EXACT:	p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (mouse) \| p4Y-MAL:PIP2:BTK:activated TLR4 (mouse)
	RELATED:	p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4

Definition

A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex. [TLR:AMM]

Comment

Evidence=(ECO:0000088, based on PR:000037448). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial transfer of LPS.

PRO Category

organism-complex

Parent

PR:000037472 TIRAP:PIP2:BTK:activated TLR4 complex

Taxon

NCBITaxon:10090 Mus musculus

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037478	PR:P35991	tyrosine-protein kinase BTK (mouse)	mBTK	A tyrosine-protein kinase BTK that is encoded in the genome of mouse. [OMA:P35991, PRO:WCB]	2
	PR:000027171	lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)	mLY96/iso:1/SigPep-/NGlyco:1	A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA]	2
	PR:000027216	Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse)	mTIRAP/Phos:1	A Toll/interleukin-1 receptor domain-containing adapter protein (mouse) that has been phosphorylated on Tyr residues by the BTK in mouse. [PRO:CNA]	2
	PR:000027172	Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)	mTLR4/iso:1/SigPep-/NGlyco:1	A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA]	2
	CHEBI:16412	lipopolysaccharide	lipopolysaccharide	Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]	2
	CHEBI:18348	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]

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