Protein Ontology Report - hCD14 PR:P08571 - http://purl.obolibrary.org/obo/PR_P08571

This page represents a class of proteins encompassing all the protein products of the CD14 gene in Homo sapiens.

Ontology Information
PRO ID	PR:P08571 Show OBO stanza / PAF / GPI
PRO name	monocyte differentiation antigen CD14 (human)
Synonyms	PRO-short-label: EXACT: hCD14 Gene-based: RELATED: CD14 Other: EXACT: myeloid cell-specific leucine-rich glycoprotein (human)
Definition	A CD14 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08571]
PRO Category	organism-gene
Parent	PR:000001889 CD14 molecule
Gene Template	HGNC:1628 CD14
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 12
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB:P08571

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hCD14 forms found in complexes

hCD14 Component Complexes PR:000001889 CD14 PR:000037465 LPS:CD14 complex PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human) PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000037464 LPS:GPI-anchored CD14 complex (human) PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000027208 ticam1:ticam2:activated TLR4 complex (human) PR:000035703 hCD14/iso:1/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human) PR:000035703 hCD14/iso:1/Clv:2/soluble PR:000037479 lipopolysaccharide receptor complex 4 (human) PR:000037480 hCD14/iso:1/Clv:2 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000037480 hCD14/iso:1/Clv:2 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000037480 hCD14/iso:1/Clv:2 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000037480 hCD14/iso:1/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035703 hCD14/iso:1/Clv:2/soluble acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 enables GO:0001530 lipopolysaccharide binding PMID:9464818 expressed_in CL:0000129 microglial cell PMID:24659539 located_in GO:0005576 extracellular region PMID:2779588, PMID:9665271 PR:000027208 ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_7861 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26016 PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 located_in GO:0005886 plasma membrane PMID:2779588, PMID:3385210, PMID:9665271 located_in GO:0005886 plasma membrane Reactome:REACT_7740 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 located_in GO:0005886 plasma membrane Reactome:REACT_152404 PR:000025773 lipopolysaccharide receptor complex 3 (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000036615 hCD14/iso:1/Clv:1/soluble located_in GO:0005576 extracellular region PMID:7519994 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282 located_in GO:0005886 plasma membrane Reactome:REACT_125282 PR:P08571 hCD14 expressed_in NOT CL:0000127 astrocyte PMID:24659539 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037 enables GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037 located_in GO:0010008 endosome membrane Reactome:REACT_124037 PR:000037464 LPS:GPI-anchored CD14 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 located_in GO:0005886 plasma membrane Reactome:REACT_7856 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25948 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882 enables GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882 located_in GO:0005886 plasma membrane Reactome:REACT_120882 PR:000037463 LPS:secreted CD14 alpha (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 located_in GO:0005615 extracellular space Reactome:REACT_7856 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005576 extracellular region PR:000035703 hCD14/iso:1/Clv:2/soluble PMID:2779588, PMID:9665271 PR:000036615 hCD14/iso:1/Clv:1/soluble PMID:7519994 GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_7861 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124037 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26016 GO:0005886 plasma membrane PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167 PMID:2779588, PMID:3385210, PMID:9665271 PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167 Reactome:REACT_7740 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) Reactome:REACT_152404 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282 PR:000037464 LPS:GPI-anchored CD14 complex (human) Reactome:REACT_7856 GO:0005615 extracellular space PR:000037463 LPS:secreted CD14 alpha (human) Reactome:REACT_7856

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