Protein Ontology Report - hFADD PR:Q13158 - http://purl.obolibrary.org/obo/PR_Q13158

This page represents a class of proteins encompassing all the protein products of the FADD gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q13158 Show OBO stanza / PAF / GPI
PRO name	FAS-associated death domain protein (human)
Synonyms	PRO-short-label: EXACT: hFADD Gene-based: RELATED: FADD | GIG3 | MORT1 Other: EXACT: FAS-associating death domain-containing protein (human) | growth-inhibiting gene 3 protein (human) | mediator of receptor induced toxicity (human)
Definition	A FAS-associated death domain protein that is encoded in the genome of human. [PRO:DNx]
PRO Category	organism-gene
Parent	PR:000002189 FAS-associated death domain protein
Gene Template	HGNC:3573 FADD
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-54639, UniProtKB:Q13158

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hFADD forms found in complexes

hFADD Component Complexes PR:Q13158 hFADD PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) PR:Q13158 hFADD PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) PR:Q13158 hFADD PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) PR:Q13158 hFADD PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human) PR:Q13158 hFADD PR:000028437 TRAF2:TRADD:RIP1:FADD (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344 located_in GO:0010008 endosome membrane Reactome:REACT_151344 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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