PRO Entry Report - PR:Q13485-1

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:Q13485-1 Show OBO stanza / PAF / GPI

PRO name

mothers against decapentaplegic homolog 4 isoform 1 (human)

Synonyms

PRO-short-label:

EXACT:

hSMAD4/iso:1

Definition

A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]

PRO Category

organism-sequence

Parent

PR:000000366 smad4 isoform 1

Taxon

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	UniProtKB:Q13485-1

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

hSMAD4/iso:1 forms found in complexes

hSMAD4/iso:1 Component	Complexes
PR:Q13485-1 hSMAD4/iso:1	PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:Q13485-1 hSMAD4/iso:1	PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:Q13485-1 hSMAD4/iso:1	PR:000025947 smad2-smad4 protein complex 4 (human)
PR:Q13485-1 hSMAD4/iso:1	PR:000025946 smad2-smad4 protein complex 3 (human)
PR:Q13485-1 hSMAD4/iso:1	PR:000025940 smad2-smad4 protein complex 2 (human)

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:Q13485-1 hSMAD4/iso:1	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:14633973
	acts_upstream_of_or_within	GO:0007183 SMAD protein complex assembly	PMID:10980615, PMID:15350224, PMID:9346966
	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:17142805, PMID:8774881
	enables	GO:0003712 transcription coregulator activity	PMID:10980615
	enables	GO:0003700 DNA-binding transcription factor activity	PMID:10823886
	located_in	GO:0005737 cytoplasm	PMID:15280432
	located_in	GO:0005634 nucleus	PMID:10980615, PMID:15280432
	part_of	GO:0005667 transcription factor complex	PMID:12374795

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:Q13485-1 hSMAD4/iso:1	PMID:10980615, PMID:15280432
GO:0005737 cytoplasm	PR:Q13485-1 hSMAD4/iso:1	PMID:15280432

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