Protein Ontology Report - hIRF3 PR:Q14653 - http://purl.obolibrary.org/obo/PR_Q14653

This page represents a class of proteins encompassing all the protein products of the IRF3 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q14653 Show OBO stanza / PAF / GPI
PRO name	interferon regulatory factor 3 (human)
Synonyms	PRO-short-label: EXACT: hIRF3 Gene-based: RELATED: IRF3 Other: EXACT: IRF-3 (human)
Definition	An interferon regulatory factor 3 that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000002045 interferon regulatory factor 3
Gene Template	HGNC:6118 IRF3
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 5 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-166251, UniProtKB:Q14653

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIRF3 forms found in complexes

hIRF3 Component Complexes PR:000025763 hIRF3/iso:1/Phos:1 PR:000036002 IRF3-P:IRF3-P:KPNA4 complex (human) PR:000028702 hIRF3/UnMod PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028702 hIRF3/UnMod PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000028702 hIRF3/UnMod PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000028702 hIRF3/UnMod PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000045488 hIRF3/Phos:1 PR:000025765 IRF3-P:IRF3-P complex (human) PR:000045489 hIRF3/iso:1/Phos:2 PR:000027084 IRF3-P:IRF7-P complex (human) PR:Q14653 hIRF3 PR:000036045 IRF3:XPO1 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036045 IRF3:XPO1 complex (human) located_in GO:0005737 cytoplasm PMID:10805757 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000025765 IRF3-P:IRF3-P complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0034340 response to type I interferon PMID:10805757 acts_upstream_of_or_within GO:0002753 cytosolic pattern recognition receptor signaling pathway Reactome:REACT_7146 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 located_in GO:0005829 cytosol Reactome:REACT_7146 located_in GO:0005634 nucleus PMID:10805757 located_in GO:0005654 nucleoplasm Reactome:REACT_7444 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000025763 hIRF3/iso:1/Phos:1 Ser-385/Ser-386, MOD:00046 enables GO:0005515 protein binding with PR:O14980 hXPO1 PMID:10805757 located_in GO:0005829 cytosol Reactome:REACT_7149 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000025763 hIRF3/iso:1/Phos:1 Ser-385/Ser-386, MOD:00046 Reactome:REACT_7149 PR:000025765 IRF3-P:IRF3-P complex (human) Reactome:REACT_7146 GO:0005654 nucleoplasm PR:000025765 IRF3-P:IRF3-P complex (human) Reactome:REACT_7444 GO:0010008 endosome membrane PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0005634 nucleus PR:000025765 IRF3-P:IRF3-P complex (human) PMID:10805757 GO:0005737 cytoplasm PR:000036045 IRF3:XPO1 complex (human) PMID:10805757

top