Protein Ontology Report - SPTLC1 PR:000015596 - http://purl.obolibrary.org/obo/PR_000015596

Ontology Information
PRO ID	PR:000015596 Show OBO stanza / PAF
PRO name	serine palmitoyltransferase 1
Synonyms	PRO-short-label: EXACT: SPTLC1 Gene-based: RELATED: LCB1 Other: EXACT: LCB 1 | SPT 1 | SPT1 | long chain base biosynthesis protein 1 | serine-palmitoyl-CoA transferase 1
Definition	A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category	gene
Parent	PR:000026126 eukaryotic serine palmitoyltransferase
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms gene 1 organism-gene 8 sequence 1 organism-sequence 3 modification 0 organism-modification 1 union 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	IUPHARobj:2509

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All gene organism-gene sequence organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

SPTLC1 forms found in complexes

SPTLC1 Component Complexes PR:O15269 hSPTLC1 PR:000026155 serine palmitoyltransferase complex A (human) PR:O15269 hSPTLC1 PR:000026154 serine palmitoyltransferase complex 6 (human) PR:O15269 hSPTLC1 PR:000026153 serine palmitoyltransferase complex 5 (human) PR:O15269 hSPTLC1 PR:000026152 serine palmitoyltransferase complex 4 (human) PR:O15269 hSPTLC1 PR:000026146 serine palmitoyltransferase complex 3 (human) PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human) PR:O15269 hSPTLC1 PR:000026145 serine palmitoyltransferase complex core 2 (human) PR:O35704 mSPTLC1 PR:000025762 serine palmitoyltransferase complex A (mouse) PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000026144 serine palmitoyltransferase complex core 1 (human) enables GO:0004758 serine C-palmitoyltransferase activity PMID:19416851 PR:O35704-1 mSPTLC1/iso:1 enables GO:0005515 protein binding with PR:P41233 mABCA1 PMID:18484747 enables NOT GO:0004758 serine C-palmitoyltransferase activity PMID:9363775 PR:O35704 mSPTLC1 acts_upstream_of_or_within GO:0046512 sphingosine biosynthetic process PMID:16216550 acts_upstream_of_or_within GO:0006686 sphingomyelin biosynthetic process PMID:16216550 acts_upstream_of_or_within GO:0046513 ceramide biosynthetic process PMID:16216550 acts_upstream_of_or_within GO:0046511 sphinganine biosynthetic process PMID:19416652 PR:000026154 serine palmitoyltransferase complex 6 (human) enables GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851 PR:000026153 serine palmitoyltransferase complex 5 (human) enables GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851

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