back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TGF-beta
PR:000000046 - http://purl.obolibrary.org/obo/PR_000000046
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000046   
  PRO nameTGF-beta 
  Synonyms
Other: EXACT:transforming growth factor beta
  Definition"A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation." [PIRSF:PIRSF001787] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 12                                        
         Sequence4                                                  Organism-Sequence 17                                        
         Modification20                                                  Organism-Modification 36                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF001787
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000046 TGF-beta
SKP1
Yes
gene


PR:000000182 TGF-beta 1
TGFB1
Yes
organism-gene


PR:P01137 transforming growth factor beta-1 (human)
hTGFB1

organism-sequence


PR:000000398 TGF-beta 1 sequence variant L10P (human)
hTGFB1/var:L10P
Yes
organism-sequence


PR:000000399 TGF-beta 1 sequence variant T81H (human)
hTGFB1/var:T81H
Yes
organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-sequence


PR:000000400 TGF-beta 1 sequence variant R218C (human)
hTGFB1/var:R218C
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-sequence


PR:000000401 TGF-beta 1 sequence variant R218H (human)
hTGFB1/var:R218H
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
organism-sequence


PR:000000402 TGF-beta 1 sequence variant H222D (human)
hTGFB1/var:H222D
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-sequence


PR:000000403 TGF-beta 1 sequence variant C225R (human)
hTGFB1/var:C225R
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human)
hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human)
hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000066327 transforming growth factor beta-1 deaminated 1 (human)
hTGFB1/Deam:1

organism-modification


PR:000069562 transforming growth factor beta-1 cysteinylated 1 (human)
hTGFB1/Cyst:1

organism-gene


PR:P04202 transforming growth factor beta-1 proprotein (mouse)
mTGFB1

organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse)
mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
organism-gene


PR:P09533 transforming growth factor beta-1 (green monkey)
GrMonkey-TGFB1

organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey)
GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-gene


PR:P17246 transforming growth factor beta-1 (rat)
rTGFB1

organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
Yes
Yes
organism-gene


PR:Q9VQG9 dawdle, isoform A (fruit fly)
fly-TGFB1

sequence


PR:000000397 TGF-beta 1 isoform 1
TGFB1/iso:1

organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human)
hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-sequence


PR:P04202-1 transforming growth factor beta-1 isoform 1 (mouse)
mTGFB1/iso:1
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
organism-sequence


PR:P09533-1 transforming growth factor beta-1 isoform 1 (green monkey)
GrMonkey-TGFB1/iso:1

organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
modification


PR:000000616 TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000002555 TGF-beta 1 isoform 1 unmodified form
TGFB1/iso:1/UnMod

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form
TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
modification


PR:000018291 TGF-beta 1, signal peptide removed form
TGFB1/SigPep-

modification


PR:000025454 TGF-beta 1 isoform 1, signal peptide removed form
TGFB1/iso:1/SigPep-

modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
modification


PR:000000618 TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive

organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036527 TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification


PR:000036529 TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
organism-modification


PR:000049430 transforming growth factor beta-1, signal peptide removed form (human)
hTGFB1/SigPep-

organism-modification


PR:000021903 TGF-beta 1 sequence variant T81H, signal peptide removed form (human)
hTGFB1/var:T81H/SigPep-

organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
hTGFB1/var:H222D/SigPep-

organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000021906 TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-

organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000021907 TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
hTGFB1/var:R218H/SigPep-

organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
modification


PR:000018292 TGF-beta 1 proteolytic cleavage product
TGFB1/ClvPrd

modification


PR:000000616 TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human)
hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human)
hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human)
hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human)
hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human)
hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human)
hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human)
hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human)
hTGFB1/var:R218H/Clv:2
Yes
gene


PR:000000183 TGF-beta 2
TGFB2
Yes
organism-gene


PR:P27090 transforming growth factor beta-2 proprotein (mouse)
mTGFB2

organism-sequence


PR:P27090-1 transforming growth factor beta-2 isoform 1 (mouse)
mTGFB2/iso:A

organism-modification


PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)
mTGFB2/iso:A/Clv:2
Yes
organism-gene


PR:P61812 transforming growth factor beta-2 (human)
hTGFB2

organism-sequence


PR:P61812-1 transforming growth factor beta-2 isoform A (human)
hTGFB2/iso:A
Yes
organism-modification


PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)
hTGFB2/iso:A/Clv:1
Yes
organism-modification


PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)
hTGFB2/iso:A/Clv:2
Yes
organism-modification


PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)
hTGFB2/iso:A/Clv:3
Yes
organism-sequence


PR:P61812-2 transforming growth factor beta-2 isoform B (human)
hTGFB2/iso:B
Yes
organism-modification


PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)
hTGFB2/iso:B/Clv:1
Yes
organism-modification


PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)
hTGFB2/iso:B/Clv:2
Yes
organism-modification


PR:000069517 transforming growth factor beta-2 methylated 1 (human)
hTGFB2/Me:1

organism-gene


PR:Q07257 transforming growth factor beta-2 proprotein (rat)
rTGFB2

organism-sequence


PR:Q07257-1 transforming growth factor beta-2 proprotein isoform rTGF-beta2B (rat)
rTGFB2/iso:rTGF-beta2B

organism-sequence


PR:Q07257-2 transforming growth factor beta-2 isoform A (rat)
rTGFB2/iso:A

sequence


PR:000000404 TGF-beta 2 isoform A
TGFB2/iso:A

organism-sequence


PR:P27090-1 transforming growth factor beta-2 isoform 1 (mouse)
mTGFB2/iso:A

organism-modification


PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)
mTGFB2/iso:A/Clv:2
Yes
organism-sequence


PR:P61812-1 transforming growth factor beta-2 isoform A (human)
hTGFB2/iso:A
Yes
organism-modification


PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)
hTGFB2/iso:A/Clv:1
Yes
organism-modification


PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)
hTGFB2/iso:A/Clv:2
Yes
organism-modification


PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)
hTGFB2/iso:A/Clv:3
Yes
organism-sequence


PR:Q07257-2 transforming growth factor beta-2 isoform A (rat)
rTGFB2/iso:A

modification


PR:000000629 TGF-beta 2 isoform A cleaved 1
TGFB2/iso:A/Clv:1

organism-modification


PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)
hTGFB2/iso:A/Clv:1
Yes
modification


PR:000021908 TGF-beta 2 isoform A, signal peptide removed form
TGFB2/iso:A/SigPep-

modification


PR:000000630 TGF-beta 2 isoform A cleaved 2
TGFB2/iso:A/Clv:2

organism-modification


PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)
mTGFB2/iso:A/Clv:2
Yes
organism-modification


PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)
hTGFB2/iso:A/Clv:2
Yes
modification


PR:000000631 TGF-beta 2 isoform A cleaved 3
TGFB2/iso:A/Clv:3

organism-modification


PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)
hTGFB2/iso:A/Clv:3
Yes
sequence


PR:000000405 TGF-beta 2 isoform B
TGFB2/iso:B

organism-sequence


PR:P61812-2 transforming growth factor beta-2 isoform B (human)
hTGFB2/iso:B
Yes
organism-modification


PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)
hTGFB2/iso:B/Clv:1
Yes
organism-modification


PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)
hTGFB2/iso:B/Clv:2
Yes
modification


PR:000000632 TGF-beta 2 isoform B cleaved 1
TGFB2/iso:B/Clv:1

organism-modification


PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)
hTGFB2/iso:B/Clv:1
Yes
modification


PR:000021909 TGF-beta 2 isoform B, signal peptide removed form
TGFB2/iso:B/SigPep-

modification


PR:000000633 TGF-beta 2 isoform B cleaved 2
TGFB2/iso:B/Clv:2

organism-modification


PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)
hTGFB2/iso:B/Clv:2
Yes
modification


PR:000018293 TGF-beta 2 proteolytic cleavage product
TGFB2/ClvPrd

modification


PR:000000629 TGF-beta 2 isoform A cleaved 1
TGFB2/iso:A/Clv:1

organism-modification


PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)
hTGFB2/iso:A/Clv:1
Yes
modification


PR:000000630 TGF-beta 2 isoform A cleaved 2
TGFB2/iso:A/Clv:2

organism-modification


PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)
mTGFB2/iso:A/Clv:2
Yes
organism-modification


PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)
hTGFB2/iso:A/Clv:2
Yes
modification


PR:000000631 TGF-beta 2 isoform A cleaved 3
TGFB2/iso:A/Clv:3

organism-modification


PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)
hTGFB2/iso:A/Clv:3
Yes
modification


PR:000000632 TGF-beta 2 isoform B cleaved 1
TGFB2/iso:B/Clv:1

organism-modification


PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)
hTGFB2/iso:B/Clv:1
Yes
modification


PR:000000633 TGF-beta 2 isoform B cleaved 2
TGFB2/iso:B/Clv:2

organism-modification


PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)
hTGFB2/iso:B/Clv:2
Yes
gene


PR:000000184 TGF-beta 3
TGFB3

organism-gene


PR:P10600 transforming growth factor beta-3 (human)
hTGFB3

organism-sequence


PR:P10600-1 transforming growth factor beta-3 isoform 1 (human)
hTGFB3/iso:1
Yes
organism-modification


PR:000036536 TGF-beta 3 isoform 1 cleaved 1 (human)
hTGFB3/iso:1/Clv:1
Yes
organism-sequence


PR:P10600-2 transforming growth factor beta-3 isoform h2 (human)
hTGFB3/iso:h2

organism-gene


PR:P16047 transforming growth factor beta-3 proprotein (chicken)
chick-TGFB3

organism-gene


PR:P17125 transforming growth factor beta-3 (mouse)
mTGFB3

organism-sequence


PR:P17125-1 transforming growth factor beta-3 isoform 1 (mouse)
mTGFB3/iso:1
Yes
organism-modification


PR:000036537 TGF-beta 3 isoform 1 cleaved 1 (mouse)
mTGFB3/iso:1/Clv:1
Yes
organism-modification


PR:000036538 TGF-beta 3 isoform 1 cleaved 3 (mouse)
mTGFB3/iso:1/Clv:3
Yes
organism-gene


PR:Q07258 transforming growth factor beta-3 proprotein (rat)
rTGFB3

sequence


PR:000000406 TGF-beta 3 isoform 1
TGFB3/iso:1

organism-sequence


PR:P10600-1 transforming growth factor beta-3 isoform 1 (human)
hTGFB3/iso:1
Yes
organism-modification


PR:000036536 TGF-beta 3 isoform 1 cleaved 1 (human)
hTGFB3/iso:1/Clv:1
Yes
organism-sequence


PR:P17125-1 transforming growth factor beta-3 isoform 1 (mouse)
mTGFB3/iso:1
Yes
organism-modification


PR:000036537 TGF-beta 3 isoform 1 cleaved 1 (mouse)
mTGFB3/iso:1/Clv:1
Yes
organism-modification


PR:000036538 TGF-beta 3 isoform 1 cleaved 3 (mouse)
mTGFB3/iso:1/Clv:3
Yes
modification


PR:000000634 TGF-beta 3 isoform 1 cleaved 1
TGFB3/iso:1/Clv:1

organism-modification


PR:000036536 TGF-beta 3 isoform 1 cleaved 1 (human)
hTGFB3/iso:1/Clv:1
Yes
organism-modification


PR:000036537 TGF-beta 3 isoform 1 cleaved 1 (mouse)
mTGFB3/iso:1/Clv:1
Yes
modification


PR:000021910 TGF-beta 3 isoform 1, signal peptide removed form
TGFB3/iso:1/SigPep-

modification


PR:000000635 TGF-beta 3 isoform 1 cleaved 2
TGFB3/iso:1/Clv:2

modification


PR:000000636 TGF-beta 3 isoform 1 cleaved 3
TGFB3/iso:1/Clv:3

organism-modification


PR:000036538 TGF-beta 3 isoform 1 cleaved 3 (mouse)
mTGFB3/iso:1/Clv:3
Yes
modification


PR:000018294 TGF-beta 3 proteolytic cleavage product
TGFB3/ClvPrd

modification


PR:000000634 TGF-beta 3 isoform 1 cleaved 1
TGFB3/iso:1/Clv:1

organism-modification


PR:000036536 TGF-beta 3 isoform 1 cleaved 1 (human)
hTGFB3/iso:1/Clv:1
Yes
organism-modification


PR:000036537 TGF-beta 3 isoform 1 cleaved 1 (mouse)
mTGFB3/iso:1/Clv:1
Yes
modification


PR:000000635 TGF-beta 3 isoform 1 cleaved 2
TGFB3/iso:1/Clv:2

modification


PR:000000636 TGF-beta 3 isoform 1 cleaved 3
TGFB3/iso:1/Clv:3

organism-modification


PR:000036538 TGF-beta 3 isoform 1 cleaved 3 (mouse)
mTGFB3/iso:1/Clv:3
Yes
Back to top
SKP1 forms found in complexes   

SKP1 Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000046 SKP1
TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF001787
GO:0042127 regulation of cell population proliferation PIRSF:PIRSF001787
enablesGO:0005160 transforming growth factor beta receptor binding PIRSF:PIRSF001787
GO:0008083 growth factor activity PIRSF:PIRSF001787
GO:0042803 protein homodimerization activity PIRSF:PIRSF001787
PR:000000182 TGFB1 acts_upstream_of_or_withinGO:0008283 cell population proliferation PANTHER:PTHR11848
GO:0030154 cell differentiation PANTHER:PTHR11848
PR:000000183 TGFB2 acts_upstream_of_or_withinGO:0008283 cell population proliferation PANTHER:PTHR11848
PR:000000398 hTGFB1/var:L10P
UniProtKB:P01137, Leu-10, CHEBI:50342		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9783545
PR:000000399 hTGFB1/var:T81H
UniProtKB:P01137, Tyr-81, CHEBI:29979		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
located_inSO:0001558 polypeptide_localization_variant PMID:11062463; PMID:12493741
PR:000000400 hTGFB1/var:R218C
UniProtKB:P01137, Arg-218, CHEBI:29950		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182
GO:0043066 negative regulation of apoptotic process PMID:11062463; PMID:12493741; PMID:12843182
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:10973241; PMID:11062463; PMID:12493741; PMID:12843182
enablesincreased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463; PMID:12493741; PMID:12843182
PR:000000401 hTGFB1/var:R218H
UniProtKB:P01137, Arg-218, CHEBI:29979		 associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
PR:000000402 hTGFB1/var:H222D
UniProtKB:P01137, His-222, CHEBI:29958		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
PR:000000403 hTGFB1/var:C225R
UniProtKB:P01137, Cys-225, CHEBI:29952		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
GO:0043066 negative regulation of apoptotic process PMID:11062463; PMID:12493741; PMID:12843182
associated_with_disease_progressionDO:4997 Camurati-Engelmann disease PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000619 hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979		 located_inSO:0001558 polypeptide_localization_variant PMID:12493741
PR:000000620 hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979		 located_inGO:0005615 extracellular space PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622 hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000623 hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741
located_inGO:0005615 extracellular space PMID:12493741
PR:000000624 hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000000625 hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952		 enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626 hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11278244
located_inGO:0005615 extracellular space PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000025927 hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000025928 mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
enablesGO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000025929 rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390		 located_inGO:0031012 extracellular matrix PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
enablesGO:0042803 protein homodimerization activity PMID:3185545
located_inGO:0031012 extracellular matrix PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1448117; PMID:2677679
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:1448117
located_inGO:0032991 protein-containing complex PMID:1448117; PMID:2677679
PR:000036529 mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000036530 hTGFB2/iso:A/Clv:1
UniProtKB:P61812-1, 303-414		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
GO:0008285 negative regulation of cell population proliferation PMID:15944186
enablesGO:0001540 amyloid-beta binding PMID:16227582
GO:0005160 transforming growth factor beta receptor binding PMID:16227582
GO:0042803 protein homodimerization activity PMID:2119582; PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036531 mTGFB2/iso:A/Clv:2
UniProtKB:P27090-1, 20-302		 enablesGO:0005515 protein binding with PR:Q07475 D0H4S114 PMID:14985127
PR:000036532 hTGFB2/iso:A/Clv:2
UniProtKB:P61812-1, 20-302		 located_inGO:0032991 protein-containing complex PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3
UniProtKB:P61812-1, 20-302, 303-414		 enablesGO:0042803 protein homodimerization activity PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036534 hTGFB2/iso:B/Clv:1
UniProtKB:P61812-2, 331-442		 located_inGO:0005615 extracellular space PMID:1777240
PR:000036535 hTGFB2/iso:B/Clv:2
UniProtKB:P61812-2, 20-330, 331-442		 located_inGO:0005615 extracellular space PMID:1777240
PR:000036536 hTGFB3/iso:1/Clv:1
UniProtKB:P10600-1, 301-412		 enablesGO:0005160 transforming growth factor beta receptor binding PMID:18243111
GO:0042803 protein homodimerization activity PMID:18243111
PR:000036537 mTGFB3/iso:1/Clv:1
UniProtKB:P17125-1, 299-410		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:000036538 mTGFB3/iso:1/Clv:3
UniProtKB:P17125-1, 30-298, 299-410		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:P01137-1 hTGFB1/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:1544940
located_inGO:0005796 Golgi lumen PMID:1544940
PR:P04202-1 mTGFB1/iso:1 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:P10600-1 hTGFB3/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:3164476
GO:0007267 cell-cell signaling PMID:3164476
PR:P17125-1 mTGFB3/iso:1 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:P61812-1 hTGFB2/iso:A enablesGO:0046982 protein heterodimerization activity PMID:2119582
PR:P61812-2 hTGFB2/iso:B enablesGO:0046982 protein heterodimerization activity PMID:17845732
located_inGO:0045177 apical part of cell PMID:17845732