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Protein Ontology report - TGF-beta 1
PR:000000182 -
http://purl.obolibrary.org/obo/PR_000000182
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000182
PRO name
TGF-beta 1
Synonyms
PRO-Short-label
:
EXACT:
TGFB1
Gene-based
:
RELATED:
TGFB
Other
:
EXACT:
TGF-beta-1
Definition
"A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA]
PRO Category
gene
Parent
PR:000000046
TGF-beta
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
5
Sequence
1
Organism-Sequence
9
Modification
7
Organism-Modification
26
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000182
TGF-beta 1, TGFB1
Yes
organism-gene
PR:P01137
transforming growth factor beta-1 (human), hTGFB1
organism-sequence
PR:000000398
TGF-beta 1 sequence variant L10P (human), hTGFB1/var:L10P
Yes
organism-sequence
PR:000000399
TGF-beta 1 sequence variant T81H (human), hTGFB1/var:T81H
Yes
organism-modification
PR:000021903
TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-sequence
PR:000000400
TGF-beta 1 sequence variant R218C (human), hTGFB1/var:R218C
Yes
organism-modification
PR:000021904
TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-sequence
PR:000000401
TGF-beta 1 sequence variant R218H (human), hTGFB1/var:R218H
Yes
organism-modification
PR:000021907
TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-sequence
PR:000000402
TGF-beta 1 sequence variant H222D (human), hTGFB1/var:H222D
Yes
organism-modification
PR:000021905
TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-sequence
PR:000000403
TGF-beta 1 sequence variant C225R (human), hTGFB1/var:C225R
Yes
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-sequence
PR:P01137-1
transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human), hTGFB1/SigPep-
organism-modification
PR:000021903
TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification
PR:000021904
TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification
PR:000021905
TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification
PR:000021907
TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification
PR:000066327
transforming growth factor beta-1 deaminated 1 (human), hTGFB1/Deam:1
organism-modification
PR:000069562
transforming growth factor beta-1 cysteinylated 1 (human), hTGFB1/Cyst:1
organism-gene
PR:P04202
transforming growth factor beta-1 proprotein (mouse), mTGFB1
organism-sequence
PR:P04202-1
transforming growth factor beta-1 isoform 1 (mouse), mTGFB1/iso:1
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-gene
PR:P09533
transforming growth factor beta-1 (green monkey), GrMonkey-TGFB1
organism-sequence
PR:P09533-1
transforming growth factor beta-1 isoform 1 (green monkey), GrMonkey-TGFB1/iso:1
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-gene
PR:P17246
transforming growth factor beta-1 (rat), rTGFB1
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-gene
PR:Q9VQG9
dawdle, isoform A (fruit fly), fly-TGFB1
sequence
PR:000000397
TGF-beta 1 isoform 1, TGFB1/iso:1
organism-sequence
PR:P01137-1
transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-sequence
PR:P04202-1
transforming growth factor beta-1 isoform 1 (mouse), mTGFB1/iso:1
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-sequence
PR:P09533-1
transforming growth factor beta-1 isoform 1 (green monkey), GrMonkey-TGFB1/iso:1
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
modification
PR:000000616
TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification
PR:000002555
TGF-beta 1 isoform 1 unmodified form, TGFB1/iso:1/UnMod
modification
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form, TGFB1/iso:1/SigPep-
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
modification
PR:000018291
TGF-beta 1, signal peptide removed form, TGFB1/SigPep-
modification
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form, TGFB1/iso:1/SigPep-
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
organism-modification
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human), hTGFB1/SigPep-
organism-modification
PR:000021903
TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification
PR:000021904
TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification
PR:000021905
TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification
PR:000021907
TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
modification
PR:000018292
TGF-beta 1 proteolytic cleavage product, TGFB1/ClvPrd
modification
PR:000000616
TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
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TGFB1
forms found in complexes
TGFB1
Component
Complexes
PR:000000616
TGFB1/iso:1/mature
PR:000025925
dimeric TGF-beta 1
PR:000025927
hTGFB1/iso:1/mature
PR:000025926
dimeric TGF-beta 1 (human)
PR:000025929
rTGFB1/iso:1/mature
PR:000025931
dimeric TGF-beta 1 (rat)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000182
TGFB1
TGFB | TGF-beta-1
"A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA]
acts_upstream_of_or_within
GO:0008283
cell population proliferation
PANTHER:PTHR11848
GO:0030154
cell differentiation
PANTHER:PTHR11848
PR:000000398
hTGFB1/var:L10P
UniProtKB:P01137, Leu-10, CHEBI:50342 | TGF-beta 1 sequence variant 1 (human)
"A transforming growth factor beta-1 (human) that has a Pro residue at the position equivalent to Leu-10 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Leu-10, CHEBI:50342." [PMID:12202987, PMID:3861940, PMID:9783545, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:9783545
PR:000000399
hTGFB1/var:T81H
UniProtKB:P01137, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 (human)
"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Tyr-81, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:12493741
located_in
SO:0001558
polypeptide_localization_variant
PMID:11062463
;
PMID:12493741
PR:000000400
hTGFB1/var:R218C
UniProtKB:P01137, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 (human)
"A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12843182
GO:0043066
negative regulation of apoptotic process
PMID:11062463
;
PMID:12493741
;
PMID:12843182
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:10973241
;
PMID:11062463
;
PMID:12493741
;
PMID:12843182
enables
increased
GO:0008083
growth factor activity
relative to
PR:000002555
TGFB1/iso:1/UnMod
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000401
hTGFB1/var:R218H
UniProtKB:P01137, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 (human)
"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:12493741
PR:000000402
hTGFB1/var:H222D
UniProtKB:P01137, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 (human)
"A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958." [PMID:12493741, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12493741
GO:0043066
negative regulation of apoptotic process
PMID:12493741
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:12493741
PR:000000403
hTGFB1/var:C225R
UniProtKB:P01137, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 (human)
"A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952." [PMID:12493741, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
;
PMID:12493741
;
PMID:12843182
GO:0043066
negative regulation of apoptotic process
PMID:11062463
;
PMID:12493741
;
PMID:12843182
associated_with_disease_progression
DO:4997
Camurati-Engelmann disease
PMID:12493741
enables
increased
GO:0008083
growth factor activity
relative to
PR:000002555
TGFB1/iso:1/UnMod
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000619
hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 1 (human)
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
located_in
SO:0001558
polypeptide_localization_variant
PMID:12493741
PR:000000620
hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 2 (human)
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
located_in
GO:0005615
extracellular space
PMID:12493741
PR:000000621
hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
;
PMID:12493741
;
PMID:12843182
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:11278244
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000622
hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
PR:000000623
hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12493741
GO:0043066
negative regulation of apoptotic process
PMID:12493741
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:12493741
located_in
GO:0005615
extracellular space
PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
SO:0001601
conformational_change_variant
PMID:11278244
PR:000000625
hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
PR:000000627
hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 1 (human)
"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11278244
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:11278244
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PMID:11278244
located_in
GO:0005615
extracellular space
PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
SO:0001601
conformational_change_variant
PMID:11278244
PR:000025927
hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:8471846
GO:0043066
negative regulation of apoptotic process
PMID:9918798
enables
GO:0042803
protein homodimerization activity
PMID:3162913
;
PMID:8471846
located_in
GO:0031012
extracellular matrix
PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390 | PRO_0000033767
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:14764882
located_in
GO:0031012
extracellular matrix
PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390 | PRO_0000033771
"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]
located_in
GO:0031012
extracellular matrix
PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390 | PRO_0000033761
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3185545
enables
GO:0042803
protein homodimerization activity
PMID:3185545
located_in
GO:0031012
extracellular matrix
PMID:3185545
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:2677679
;
PMID:3162913
GO:0042803
protein homodimerization activity
PMID:3162913
located_in
GO:0031012
extracellular matrix
PMID:17015622
;
PMID:8294500
GO:0032991
protein-containing complex
PMID:3162913
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]
located_in
GO:0032991
protein-containing complex
PMID:17015622
;
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033760, PRO_0000033761, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1448117
;
PMID:2677679
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:1448117
located_in
GO:0032991
protein-containing complex
PMID:1448117
;
PMID:2677679
PR:000036529
mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033766, PRO_0000033767, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
located_in
GO:0031012
extracellular matrix
PMID:9008713
PR:P01137-1
hTGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1544940
GO:0043066
negative regulation of apoptotic process
PMID:9918798
enables
GO:0042803
protein homodimerization activity
PMID:1544940
located_in
GO:0005796
Golgi lumen
PMID:1544940
PR:P04202-1
mTGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856