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Protein Ontology Report - hMAD2L1

PR:Q13257 - http://purl.obolibrary.org/obo/PR_Q13257
This page represents a class of proteins encompassing all the protein products of the MAD2L1 gene in human.
Ontology Information
PRO ID PR:Q13257 Show OBO stanza / PAF
PRO name mitotic spindle assembly checkpoint protein MAD2A (human)
Synonyms
PRO-short-label: hMAD2L1
EXACT: HsMAD2; MAD2-like protein 1 (human); mitotic arrest deficient 2-like protein 1 (human)
Gene-based: MAD2; MAD2L1
Definition A mitotic spindle assembly checkpoint protein MAD2A that is encoded in the genome of human. [PMID:12719470, PMID:15525512, PMID:15592459, PMID:20624902, PRO:KER]
PRO Category organism-gene
Parent PR:000010038 mitotic spindle assembly checkpoint protein MAD2A
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMAD2L1 forms found in complexes
hMAD2L1 Component Complexes
PR:000042259 hMAD2L1/InitMet- PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:Q13257 hMAD2L1 PR:000035568 MAD1:MAD2 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q13257
hMAD2L1
capable_of GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 BioGRID:BG-718929, MINT:MINT-8289277
capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:20624902
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 BioGRID:BG-718926
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:20624902
capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302957
capable_of GO:0031625 ubiquitin protein ligase binding PMID:20624902
capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_in GO:0000776 kinetochore PMID:12719470
participates_in NOT GO:0051310 metaphase plate congression PMID:15592459
participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
Biological Process GO Term Protein Forms & Complexes Evidence
NOT GO:0051310 metaphase plate congression PR:Q13257 hMAD2L1

PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PR:Q13257 hMAD2L1

PMID:15525512
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:Q13257 hMAD2L1

PMID:12719470

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