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Protein Ontology Report - TLR3

PR:000001154 - http://purl.obolibrary.org/obo/PR_000001154
Ontology Information
PRO ID PR:000001154 Show OBO stanza / PAF
PRO name Toll-like receptor 3
Synonyms
PRO-short-label: EXACT: TLR3
Other: EXACT: CD283
Definition A Toll-like receptor that is a translation product of the human TLR3 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001096 Toll-like receptor
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 2
modification 1 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TLR3 forms found in complexes
TLR3 Component Complexes
PR:000001154 TLR3 PR:000037302 viral dsRNA:TLR3 complex
PR:000037305 hTLR3/SigPep- PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037303 viral dsRNA:TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037789 mTLR3/SigPep- PR:000037304 viral dsRNA:TLR3 complex (mouse)
PR:000037789 mTLR3/SigPep- PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:000037789 mTLR3/SigPep- PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)
PR:000037789 mTLR3/SigPep- PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:000037789 mTLR3/SigPep- PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:Q0PQ88 chick-TLR3 PR:000037461 viral dsRNA:TLR3 complex (chicken)
PR:Q0PQ88 chick-TLR3 PR:000037462 ticam1:viral dsRNA:TLR3 complex (chicken)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037362
K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037344
traf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037313
tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:12133833, PMID:17327220
PR:000037461
viral dsRNA:TLR3 complex (chicken)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_24923
located_in GO:0010008 endosome membrane Reactome:REACT_24923
PR:000037308
ticam1:viral dsRNA:TLR3 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12539043
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:12539043
PR:000037310
traf3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037303
viral dsRNA:TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037315
K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037304
viral dsRNA:TLR3 complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:18420935
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18420935
PR:000037307
ticam1:viral dsRNA:TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037311
traf3:ticam1:activated TLR3 complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:16306936, PMID:16306937
PR:000037330
SARM:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037322
p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037332
rip3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037334
rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037340
pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037336
rip1:rip3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037303 viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037461 viral dsRNA:TLR3 complex (chicken)

Reactome:REACT_24923

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