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Protein Ontology Report - IRAK4:MYD88:TIRAP:activated TLR complex

PR:000027193 - http://purl.obolibrary.org/obo/PR_000027193
Ontology Information
PRO ID PR:000027193 Show OBO stanza / PAF
PRO name IRAK4:MYD88:TIRAP:activated TLR complex
Synonyms
Other: EXACT: IRAK4:MyD88:Mal:activated TLR complex
Definition A protein-containing complex that is composed of activated Toll-like receptor (TLR) complexed with MyD88, Tirap/Mal, and IRAK4. [PMID:12538665, PMID:17141195, TLR:AMM]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 2 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000027182 PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein TIRAP A protein that is a translation product of the human TIRAP gene or a 1:1 ortholog thereof. [PRO:CNA] 2
PR:000001155 Toll-like receptor 4 TLR4 A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof. [PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000001740 myeloid differentiation primary response protein MyD88 MYD88 A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. [PMID:9575168, PRO:CNA] 2
PR:000003296 lymphocyte antigen 96 LY96 A protein that is a translation product of the human LY96 gene or a 1:1 ortholog thereof. [TLR:AMM] 2
PR:000001780 interleukin-1 receptor-associated kinase 4 IRAK4 A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity. [PMID:11960013, PMID:16177054, PRO:CNA]
PR:000027183 PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human) hMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:P58753-1 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human) hTIRAP/iso:1 A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM]
PR:000027184 interleukin-1 receptor-associated kinase 4 unmodified form (human) hIRAK4/UnMod An interleukin-1 receptor-associated kinase 4 unmodified form in human. [PRO:CNA]
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000027187 PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse) mMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA]
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA]
PR:000027181 interleukin-1 receptor-associated kinase 4 unmodified form (mouse) mIRAK4/UnMod An interleukin-1 receptor-associated kinase 4 unmodified form in mouse. [PRO:CNA]
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000027192 PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human) hMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:P58753-1 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human) hTIRAP/iso:1 A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM]
PR:000027191 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human) hIRAK4/iso:1/Phos:1 An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046. [PMID:17141195, PRO:CNA]
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894

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