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Protein Ontology Report - MYD88

PR:000001740 - http://purl.obolibrary.org/obo/PR_000001740
Ontology Information
PRO ID PR:000001740 Show OBO stanza / PAF
PRO name myeloid differentiation primary response protein MyD88
Synonyms
PRO-short-label: EXACT: MYD88
Definition A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. [PMID:9575168, PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 6
sequence 2 organism-sequence 10
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

MYD88 forms found in complexes
MYD88 Component Complexes
PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000001740 MYD88 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:A5HNF6 chick-MYD88 PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)
PR:P22366-1 mMYD88/iso:1 PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:P22366-1 mMYD88/iso:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:P22366-2 mMYD88/iso:2 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:Q99836 hMYD88 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001740
MYD88
has_part Pfam:PF00531 Death domain
has_part Pfam:PF01582 TIR domain
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:P22366-2
mMYD88/iso:2
participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037475
MYD88:TIRAP:activated TLR4 receptor (chicken)
located_in GO:0005886 plasma membrane Reactome:REACT_26615
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25089
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_25089
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)

PMID:12538665
PR:P22366-2 mMYD88/iso:2

PMID:12538665
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_25089
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_25089
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_26615

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