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Protein Ontology Report - IRAK1:IRAK4:MYD88:TIRAP:activated TLR4

PR:000027219 - http://purl.obolibrary.org/obo/PR_000027219
Ontology Information
PRO ID PR:000027219 Show OBO stanza / PAF
PRO name IRAK1:IRAK4:MYD88:TIRAP:activated TLR4
Synonyms
Other: EXACT: IRAK1:IRAK4:MyD88:Mal:activated TLR4
Definition A protein-containing complex that is composed of the activated TLR4 receptor, Mal, MyD88, IRAK1 and IRAK4. [PMID:12538665, TLR:AMM]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000027495 PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human) hMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human. [PRO:CNA] 6
PR:P58753 Toll/interleukin-1 receptor domain-containing adapter protein (human) hTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human. [PRO:CNA] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000027191 interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human) hIRAK4/iso:1/Phos:1 An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046. [PMID:17141195, PRO:CNA] 4
PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human) hIRAK1/iso:1/Phos:1 An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047. [PRO:DNx, UniProtKB:P51617] 4
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000027221 PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse) mMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA]
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA]
PR:000027181 interleukin-1 receptor-associated kinase 4 unmodified form (mouse) mIRAK4/UnMod An interleukin-1 receptor-associated kinase 4 unmodified form in mouse. [PRO:CNA]
PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse) mIRAK1/iso:1/Phos:1 An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047. [PMID:12538665, TLR:AMM]
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]
PR:000027220 PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse) mMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA]
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA]
PR:000027181 interleukin-1 receptor-associated kinase 4 unmodified form (mouse) mIRAK4/UnMod An interleukin-1 receptor-associated kinase 4 unmodified form in mouse. [PRO:CNA]
PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse) mIRAK1/iso:1/UnMod An interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form in mouse. [PRO:CNA]
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894

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