back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - BUB1/BUB1B protein
PR:000035665 - http://purl.obolibrary.org/obo/PR_000035665
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035665   
  PRO nameBUB1/BUB1B protein 
  Definition"A protein that consists of a core domain composition consisting of a the Mad3/BUB1 homology region 1 (Pfam:PF00831) and a C-terminal Protein kinase domain (Pfam:PF00069). Members of this class are related to MAD3." [PMID:22698286, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 11                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification15                                                  Organism-Modification 49                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000035665

BUB1/BUB1B protein

hAURKB/Phos:1


"A protein that consists of a core domain composition consisting of a the Mad3/BUB1 homology region 1 (Pfam:PF00831) and a C-terminal Protein kinase domain (Pfam:PF00069). Members of this class are related to MAD3." [PMID:22698286, PRO:CNA]


gene



PR:000004854

mitotic checkpoint serine/threonine-protein kinase BUB1

BUB1


"A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]


organism-gene



PR:O08901

mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse)

mBUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of mouse." [OMA:O08901, PMID:19965387, PMID:20057499, PRO:KER]

Yes

organism-modification



PR:000035408

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse)

mBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in mouse." [PMID:11792804, PRO:KER]


organism-modification



PR:000035416

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse)

mBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in mouse." [PRO:CNA]


organism-gene



PR:O22806

mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana)

At-BUBR1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]


organism-sequence



PR:O22806-1

mitotic spindle checkpoint protein BUBR1 isoform 1 (Arabidopsis thaliana)

At-BUBR1/iso:1


"A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-1." [PRO:DNx, UniProtKB:O22806]


organism-sequence



PR:O22806-2

mitotic spindle checkpoint protein BUBR1 isoform 2 (Arabidopsis thaliana)

At-BUBR1/iso:2


"A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-2." [PRO:DNx, UniProtKB:O22806]


organism-gene



PR:O43683

mitotic checkpoint serine/threonine-protein kinase BUB1 (human)

hBUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]

Yes

Yes
organism-sequence



PR:O43683-1

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human)

hBUB1/iso:h1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-1." [PRO:DNx, UniProtKB:O43683]


organism-sequence



PR:O43683-2

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human)

hBUB1/iso:h2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-2." [PRO:DNx, UniProtKB:O43683]


organism-sequence



PR:O43683-3

mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human)

hBUB1/iso:h3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-3." [PRO:DNx, UniProtKB:O43683]


organism-modification



PR:000035399

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)

hBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]


organism-modification



PR:000035405

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)

hBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]

Yes

organism-modification



PR:000035407

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)

hBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035412

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)

hBUB1/Phos:7


"A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]

Yes

Yes
organism-modification



PR:000035418

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)

hBUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]


organism-modification



PR:000035421

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)

hBUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]

Yes

organism-modification



PR:000065566

mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 1 (human)

hBUB1/Cyst:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-911 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-911, MOD:00765." [IEDB_epitope:933065, PRO:DNx]


organism-modification



PR:000066031

mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 2 (human)

hBUB1/Cyst:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-339 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-339, MOD:00765." [IEDB_epitope:1568023, PRO:DNx]


organism-modification



PR:000071538

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 1 (human)

hBUB1/Me:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-407 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-407, MOD:00660." [IEDB_epitope:1004377, PRO:DNx]


organism-modification



PR:000072604

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 1 (human)

hBUB1/Deam:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Gln-680 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Gln-680, MOD:00685." [IEDB_epitope:1995227, PRO:DNx]


organism-modification



PR:000073548

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (human)

hBUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-661 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Ser-661, MOD:00046." [IEDB_epitope:610301, PRO:DNx]


organism-modification



PR:000073549

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 2 (human)

hBUB1/Deam:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-879 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-879, MOD:00684." [IEDB_epitope:1590063, PRO:DNx]


organism-modification



PR:000076189

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 3 (human)

hBUB1/Deam:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-91 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-91, MOD:00684." [IEDB_epitope:1340837, PRO:DNx]


organism-modification



PR:000076708

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 4 (human)

hBUB1/Deam:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Asn-860 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Asn-860, MOD:00684." [IEDB_epitope:1573110, PRO:DNx]


organism-modification



PR:000076926

mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 5 (human)

hBUB1/Deam:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been deaminated on the residue at the position equivalent to Gln-123 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Gln-123, MOD:00685." [IEDB_epitope:1350453, PRO:DNx]


organism-modification



PR:000078756

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 2 (human)

hBUB1/Me:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-997 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-997, MOD:00660." [IEDB_epitope:1056400, PRO:DNx]


organism-modification



PR:000079803

mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 3 (human)

hBUB1/Me:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that has been methylated on the residue at the position equivalent to Cys-339 of the amino acid sequence represented by UniProtKB:O43683-1. Example: UniProtKB:O43683-1, Cys-339, MOD:00660." [IEDB_epitope:1008541, IEDB_epitope:1031438, PRO:DNx]


organism-gene



PR:Q21776

mitotic checkpoint serine/threonine-protein kinase bub-1 (worm)

BUB1 (worm)


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of worm." [PANTHER:PTHR14030:SF0, PRO:DNx]


organism-gene



PR:Q54CV5

probable inactive serine/threonine-protein kinase bub1 (Dictyostelium discoideum)

Dicty-BUB1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Dictyostelium discoideum." [PANTHER:PTHR14030:SF0, PRO:DNx]


organism-gene



PR:Q6GPC9

mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)

frog-bub1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of frog." [PRO:DNx, UniProtKB:Q6GPC9]


organism-sequence



PR:Q98UH3

mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog)

frog-BUB1/var:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q98UH3." [PMID:11231148, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000029911

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)

frog-BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]

Yes

organism-modification



PR:000029913

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)

frog-BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]


organism-modification



PR:000029917

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)

frog-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035404

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)

frog-BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]

Yes

modification



PR:000029910

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1

BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated as a result of activation of the MAPK pathway." [PMID:11231148, PRO:KER]


organism-modification



PR:000029911

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)

frog-BUB1/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]

Yes

modification



PR:000029912

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2

BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated by autocatalysis." [PMID:11231148, PRO:KER]


organism-modification



PR:000029913

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)

frog-BUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]


organism-modification



PR:000035399

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)

hBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]


organism-modification



PR:000035401

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (yeast)

yBUB1/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in yeast." [PMID:7969164, PRO:KER]


modification



PR:000029916

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000029917

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)

frog-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035405

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)

hBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]

Yes

organism-modification



PR:000035414

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in Schizosaccharomyces pombe 972h-." [PRO:CNA]


organism-modification



PR:000035415

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (yeast)

yBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in yeast." [PRO:CNA]


organism-modification



PR:000035416

mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse)

mBUB1/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in mouse." [PRO:CNA]


modification



PR:000035403

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3

BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been hyperphosphorylated within the amino-terminal noncatalytic region and induced by a lack of microtubule occupancy at kinetochores. Example: UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]


organism-modification



PR:000035404

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)

frog-BUB1/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]

Yes

modification



PR:000035406

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4

BUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to spindle damage (including treatment with taxol)." [PMID:11792804, PMID:15525512, PRO:KER]


organism-modification



PR:000035407

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)

hBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]

Yes

organism-modification



PR:000035408

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse)

mBUB1/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in mouse." [PMID:11792804, PRO:KER]


modification



PR:000035413

BUB1 CDK-consensus sites phosphorylated form

BUB1/PhosRes+


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is phosphorylated on CDK consensus sites (S/T-P-X-K/R) located in the middle region of BUB1." [PMID:12606573, PMID:16760428, PRO:KER]


organism-modification



PR:000035411

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/Phos:6


"A BUB1 CDK-consensus sites phosphorylated form in Schizosaccharomyces pombe 972h-. The exact combination of phosphorylated sites is not known but may involve Thr-340, Thr-423, Thr-455, and/or Ser-466 of the amino acid sequence represented by UniProtKB:O94751. UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)." [PMID:12606573, PRO:DAN, PRO:KER]

Yes

organism-modification



PR:000035412

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)

hBUB1/Phos:7


"A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]

Yes

Yes
organism-modification



PR:000035419

mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast)

yBUB1/Phos:CDK-1


"A BUB1 CDK-consensus sites phosphorylated form in yeast that has phosphorylation at Thr-566. This phosphorylation is essential for deactivating the spindle checkpoint in anaphase and adaptation to prolonged mitotic arrest. UniProtKB:P41695, Thr-566, MOD:00047." [PMID:21298086, PRO:KER]

Yes

modification



PR:000035417

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8

BUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated on the residue at the position equivalent to Thr-609 (by CDK1) and that has been phosphorylated on at least one residue by PLK1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:DAN, PRO:KER]


organism-modification



PR:000035418

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)

hBUB1/Phos:8


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]


modification



PR:000035420

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10

BUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to DNA damage, mitosis or spindle depolymerization. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]


organism-modification



PR:000035421

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)

hBUB1/Phos:10


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]

Yes

modification



PR:000035691

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5

BUB1/Phos:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 that represents the basal phosphorylated state observed during interphase and mitosis." [PRO:CNA, PRO:DAN]


organism-modification



PR:000035410

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-)

Spom972h-BUB1/Phos:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 in Schizosaccharomyces pombe 972h-. This form represents the basal phosphorylated state observed during interphase and mitosis." [PMID:12606573, PRO:KER]

Yes

gene



PR:000004855

mitotic checkpoint serine/threonine-protein kinase BUB1 beta

BUB1B


"A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]


organism-gene



PR:O60566

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)

hBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566]

Yes

Yes
organism-sequence



PR:O60566-1

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human)

hBUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


organism-sequence



PR:O60566-2

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human)

hBUB1B/iso:h2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-2." [PRO:DNx, UniProtKB:O60566]


organism-sequence



PR:O60566-3

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human)

hBUB1B/iso:h3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-3." [PRO:DNx, UniProtKB:O60566]


organism-modification



PR:000035362

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)

hBUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]

Yes

organism-modification



PR:000035373

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)

hBUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA]

Yes

Yes
organism-modification



PR:000035428

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)

hBUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]

Yes

Yes
organism-modification



PR:000035432

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

hBUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

Yes

organism-modification



PR:000035435

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)

hBUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]

Yes

organism-modification



PR:000065892

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 1 (human)

hBUB1B/Me:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-356 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-356, MOD:00660." [IEDB_epitope:1044994, PRO:DNx]


organism-modification



PR:000066223

mitotic checkpoint serine/threonine-protein kinase BUB1 beta cysteinylated 1 (human)

hBUB1B/Cyst:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been cysteinylated on the residue at the position equivalent to Cys-775 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-775, MOD:00765." [IEDB_epitope:1338170, PRO:DNx]


organism-modification



PR:000070779

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 1 (human)

hBUB1B/Deam:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-652 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-652, MOD:00685." [IEDB_epitope:889434, PRO:DNx]


organism-modification



PR:000074218

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 2 (human)

hBUB1B/Deam:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-56 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-56, MOD:00685." [IEDB_epitope:1584837, PRO:DNx]


organism-modification



PR:000074309

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 2 (human)

hBUB1B/Me:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-775 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-775, MOD:00660." [IEDB_epitope:1061689, PRO:DNx]


organism-modification



PR:000076756

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 3 (human)

hBUB1B/Me:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-51 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-51, MOD:00660." [IEDB_epitope:1001673, PRO:DNx]


organism-modification



PR:000077474

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 4 (human)

hBUB1B/Me:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-841 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-841, MOD:00660." [IEDB_epitope:1019154, PRO:DNx]


organism-modification



PR:000077494

mitotic checkpoint serine/threonine-protein kinase BUB1 beta deaminated 3 (human)

hBUB1B/Deam:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been deaminated on the residue at the position equivalent to Gln-57 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Gln-57, MOD:00685." [IEDB_epitope:1584838, PRO:DNx]


organism-modification



PR:000078944

mitotic checkpoint serine/threonine-protein kinase BUB1 beta methylated 5 (human)

hBUB1B/Me:5


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been methylated on the residue at the position equivalent to Cys-832 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Cys-832, MOD:00660." [IEDB_epitope:1062323, PRO:DNx]


organism-modification



PR:000080893

mitotic checkpoint serine/threonine-protein kinase BUB1 beta citrullinated 1 (human)

hBUB1B/Cit:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that has been citrullinated on the residue at the position equivalent to Arg-786 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Arg-786, MOD:00219." [IEDB_epitope:911971, PRO:DNx]


organism-gene



PR:P41695

spindle assembly checkpoint serine/threonine-protein kinase BUB1 (yeast)

yBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of yeast." [OMA:P41695, PRO:CNA, PRO:DAN]

Yes

Yes
organism-gene



PR:Q800D4

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (chicken)

chick-BUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of chicken." [PMID:17276342, PRO:KER]

Yes

organism-gene



PR:Q8JGT8

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (frog)

frog-BUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of frog." [PMID:12163471, PMID:15241477, PMID:16950116, PRO:KER]

Yes

Yes
organism-modification



PR:000035425

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog)

frog-BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in frog." [PRO:CNA]


organism-modification



PR:000035426

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog)

frog-BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER]

Yes

organism-modification



PR:000035430

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)

frog-BUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER]

Yes

organism-modification



PR:000035433

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog)

frog-BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in frog. UniProtKB:Q8JGT8, Thr-593, MOD:00047." [PMID:22801780, PRO:KER]


organism-gene



PR:Q9Z1S0

mitotic checkpoint serine/threonine-protein kinase BUB1 beta (mouse)

mBUB1B


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of mouse." [OMA:Q9Z1S0, PRO:DNx]


sequence



PR:000028795

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1

BUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-1 or a 1:1 ortholog thereof." [PMID:19407811, PRO:PD]


organism-sequence



PR:O60566-1

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human)

hBUB1B/iso:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


modification



PR:000028797

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1

BUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that has been acetylated on the Lys residue within the conserved sequence RVGGALKA. Example: UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


organism-modification



PR:000028798

mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human)

hBUB1B/iso:1/Ac:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD]


modification



PR:000035361

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1

BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-620 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]


organism-modification



PR:000035362

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human)

hBUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER]

Yes

organism-modification



PR:000035426

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (frog)

frog-BUB1B/Phos:1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER]

Yes

modification



PR:000035372

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form

BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000035373

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human)

hBUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA]

Yes

Yes
organism-modification



PR:000035425

mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (frog)

frog-BUB1B/PhosRes-


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in frog." [PRO:CNA]


modification



PR:000035427

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form

BUB1B/Phos:CDK1+PLK1


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated at one or more CDK1 and PLK1 consensus sites. The phosphorylation at CDK1 site(s) is necessary for the phosphorylation at the PLK1 site(s) to occur. Example: UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PRO:KER]


organism-modification



PR:000035428

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)

hBUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER]

Yes

Yes
organism-modification



PR:000035430

mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)

frog-BUB1B/Phos:2


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER]

Yes

modification



PR:000035431

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3

BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-608 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]


organism-modification



PR:000035432

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

hBUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

Yes

organism-modification



PR:000035433

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog)

frog-BUB1B/Phos:3


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in frog. UniProtKB:Q8JGT8, Thr-593, MOD:00047." [PMID:22801780, PRO:KER]


modification



PR:000035434

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4

BUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on residues at positions equivalent to Ser-543, Ser-670, and Ser-1043 of the amino acid sequence represented by UniProtKB:O60566-1. Additional Ser residues could be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]


organism-modification



PR:000035435

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)

hBUB1B/Phos:4


"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER]

Yes

Back to top
hAURKB/Phos:1 forms found in complexes   

hAURKB/Phos:1 Component
Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human)
PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:000035576 BUB1:BUB3:APC complex (human)
PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:000035563 BUB1B:BUB3 complex (human)
PR:000035575 BUB1B:CDC20 complex (human)
PR:P41695 yBUB1B PR:000035565 BUB1:BUB3 complex (yeast)
PR:Q8JGT8 frog-BUB1B PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029911 frog-BUB1/Phos:1
Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)
enablesincreased GO:0016301 kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:11231148
PR:000035362 hBUB1B/Phos:1
Example: UniProtKB:O60566-1, Thr-620, MOD:00047
enablesincreased GO:0005515 protein binding with PR:P53350 hPLK1 PMID:17785528
PR:000035373 hBUB1B/PhosRes- acts_upstream_of_or_withinGO:0001933 negative regulation of protein phosphorylation PMID:22801780
GO:0010826 negative regulation of centrosome duplication PMID:19503101
GO:0033673 negative regulation of kinase activity PMID:19503101
enablesGO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_inGO:0000776 kinetochore PMID:22801780
GO:0005813 centrosome PMID:19503101
PR:000035404 frog-BUB1/Phos:3
UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046
acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
enablesincreased GO:0004672 protein kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:15241477
PR:000035405 hBUB1/PhosRes- enablesNOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_inGO:0000776 kinetochore PMID:16760428
PR:000035407 hBUB1/Phos:4 enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
PR:000035410 Spom972h-BUB1/Phos:5
This form represents the basal phosphorylated state observed during interphase and mitosis
acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
PR:000035411 Spom972h-BUB1/Phos:6
UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)
acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
located_inGO:0000776 kinetochore PMID:12606573
PR:000035412 hBUB1/Phos:7
Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047
acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:16760428
enablesincreased GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428
PR:000035419 yBUB1/Phos:CDK-1
UniProtKB:P41695, Thr-566, MOD:00047
acts_upstream_of_or_withinNOT GO:0031577 spindle checkpoint signaling PMID:21298086
PR:000035421 hBUB1/Phos:10
Example: UniProtKB:O43683-1, Ser-314, MOD:00046
acts_upstream_of_or_withinGO:0006281 DNA repair PMID:22071147
GO:0031577 spindle checkpoint signaling PMID:22099307
enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_inGO:0035861 site of double-strand break PMID:22071147
PR:000035426 frog-BUB1B/Phos:1
UniProtKB:Q8JGT8, Thr-605, MOD:00047
acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
GO:0034501 protein localization to kinetochore PMID:17998400
enablesincreased GO:0005515 protein binding with PR:P70032 frog-plk1 PMID:17998400
PR:000035428 hBUB1B/Phos:2
Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)
acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597
located_inGO:0000776 kinetochore PMID:17785528
PR:000035430 frog-BUB1B/Phos:2
UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17998400
PR:000035432 hBUB1B/Phos:3
Example: UniProtKB:O60566-1, Thr-608, MOD:00047
acts_upstream_of_or_withindecreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_inGO:0000776 kinetochore PMID:22801780
PR:000035435 hBUB1B/Phos:4
Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046
acts_upstream_of_or_withinincreased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317; PMID:20016069
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
located_inGO:0000776 kinetochore PMID:19015317
PR:O08901 mBUB1 acts_upstream_of_or_withinGO:0043069 negative regulation of programmed cell death PMID:20057499
located_inGO:0000775 chromosome, centromeric region PMID:19965387
PR:O43683 hBUB1 acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:16580887
GO:0007062 sister chromatid cohesion PMID:16580887
GO:0031577 spindle checkpoint signaling PMID:15525512
GO:0043066 negative regulation of apoptotic process PMID:19252416
GO:0043069 negative regulation of programmed cell death PMID:20057499
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
enablesGO:0004672 protein kinase activity PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P04637-1 PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:P53350 hPLK1 PMID:10198256
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
GO:0005515 protein binding PMID:10198256
located_inGO:0000776 kinetochore PMID:20624902
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804; PMID:16760428
PR:O60566 hBUB1B acts_upstream_of_or_withinGO:0006469 negative regulation of protein kinase activity PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:11030144
GO:0031647 regulation of protein stability PMID:17671183
NOT GO:0034501 protein localization to kinetochore PMID:16760428
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:15592459
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
enablesGO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 BioGRID:BG-682429
GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- BioGRID:BG-682429
GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-682429
GO:0005515 protein binding with PR:O15379 HD3 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O43684 BUB3 BioGRID:BG-682429
GO:0005515 protein binding with PR:O76070 BCSG1 BioGRID:BG-682429
GO:0005515 protein binding with PR:O95997 EAP1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P04049 cRaf (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P04637-1 BioGRID:BG-682429
GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:P25054 APC BioGRID:BG-682429
GO:0005515 protein binding with PR:P51587 BRCA2 BioGRID:BG-682429
GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q02224 CENP-E (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13042 ANAPC6 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q13547 HD1 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92769 HD2 (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human) BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96GD4 AIK2 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q96IF1 AJUBA BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9H4B4 CNK BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX3 ANAPC7 BioGRID:BG-682429
GO:0005515 protein binding with PR:Q9UJX5 ANAPC4 BioGRID:BG-682429
GO:0016301 kinase activity PMID:11030144
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_inGO:0000776 kinetochore PMID:12719470; PMID:16760428
GO:0000922 spindle pole PMID:15190214
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804
GO:0005737 cytoplasm PMID:10749118
PR:P41695 yBUB1B acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
enablesGO:0005515 protein binding with PR:000035536 UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047 PMID:7969164
GO:0005515 protein binding with PR:P26449 BUB3 PMID:7969164
located_inGO:0000776 kinetochore PMID:22521787
PR:Q800D4 chick-BUB1B located_inGO:0000776 kinetochore PMID:17276342
PR:Q8JGT8 frog-BUB1B acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0032092 positive regulation of protein binding PMID:12163471
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0034501 protein localization to kinetochore PMID:17709426
GO:0051310 metaphase chromosome alignment PMID:17709426
enablesGO:0004672 protein kinase activity PMID:12163471
GO:0005515 protein binding with PR:P70039 apc PMID:12163471
GO:0005515 protein binding with PR:P79935 frog-MAD2L1 PMID:12163471
GO:0005515 protein binding with PR:Q6DFD4 fizzy PMID:12163471
GO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:12163471
GO:0005515 protein binding PMID:12163471
located_inGO:0000776 kinetochore PMID:12163471; PMID:17709426
GO:0005694 chromosome PMID:15241477; PMID:16950116
PR:Q98UH3 frog-BUB1/var:1 acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:12163471
enablesGO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:11231148
located_inGO:0000776 kinetochore PMID:11231148; PMID:12163471
GO:0005694 chromosome PMID:15241477; PMID:16950116