PRO Term |
GO Annotation |
Evidence |
PR:000029911 frog-BUB1/Phos:1 xBUB1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER] |
enables | increased GO:0016301 kinase activity relative to PR:000029917 frog-BUB1/PhosRes- |
PMID:11231148 |
PR:000035362 hBUB1B/Phos:1 UniProtKB:O60566, Thr-620, MOD:00047 | UniProtKB:O60566-1, Thr-620, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER] |
enables | increased GO:0005515 protein binding with PR:P53350 hPLK1 |
PMID:17785528 |
PR:000035373 hBUB1B/PhosRes-
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA] |
acts_upstream_of_or_within | GO:0001933 negative regulation of protein phosphorylation |
PMID:22801780 |
GO:0010826 negative regulation of centrosome duplication |
PMID:19503101 |
GO:0033673 negative regulation of kinase activity |
PMID:19503101 |
enables | GO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- |
PMID:19503101 |
located_in | GO:0000776 kinetochore |
PMID:22801780 |
GO:0005813 centrosome |
PMID:19503101 |
PR:000035404 frog-BUB1/Phos:3 UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046 | xBUB1 hyperphosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER] |
acts_upstream_of_or_within | GO:0031577 spindle checkpoint signaling |
PMID:15241477 |
GO:0034501 protein localization to kinetochore |
PMID:15241477 |
GO:0034501 protein localization to kinetochore |
PMID:15241477 |
GO:0034501 protein localization to kinetochore |
PMID:15241477 |
enables | increased GO:0004672 protein kinase activity relative to PR:000029917 frog-BUB1/PhosRes- |
PMID:15241477 |
PR:000035405 hBUB1/PhosRes-
"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA] |
enables | NOT GO:0005515 protein binding with PR:P53350 hPLK1 |
PMID:16760428 |
located_in | GO:0000776 kinetochore |
PMID:16760428 |
PR:000035407 hBUB1/Phos:4 hBUB1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER] |
enables | increased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- |
PMID:15525512 |
PR:000035410 Spom972h-BUB1/Phos:5
"A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 in Schizosaccharomyces pombe 972h-. This form represents the basal phosphorylated state observed during interphase and mitosis." [PMID:12606573, PRO:KER] |
acts_upstream_of_or_within | GO:0007094 mitotic spindle assembly checkpoint signaling |
PMID:12606573 |
GO:0045143 homologous chromosome segregation |
PMID:12606573 |
PR:000035411 Spom972h-BUB1/Phos:6 UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046) "A BUB1 CDK-consensus sites phosphorylated form in Schizosaccharomyces pombe 972h-. The exact combination of phosphorylated sites is not known but may involve Thr-340, Thr-423, Thr-455, and/or Ser-466 of the amino acid sequence represented by UniProtKB:O94751. UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)." [PMID:12606573, PRO:DAN, PRO:KER] |
acts_upstream_of_or_within | GO:0007094 mitotic spindle assembly checkpoint signaling |
PMID:12606573 |
GO:0045143 homologous chromosome segregation |
PMID:12606573 |
located_in | GO:0000776 kinetochore |
PMID:12606573 |
PR:000035412 hBUB1/Phos:7 UniProtKB:O43683, Ser-593, MOD:00046|Thr-609, MOD:00047 | UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047 "A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER] |
acts_upstream_of_or_within | GO:0034501 protein localization to kinetochore |
PMID:16760428 |
enables | increased GO:0005515 protein binding with PR:Q9NQS7 hINCENP |
PMID:16760428 |
PR:000035419 yBUB1/Phos:CDK-1 UniProtKB:P41695, Thr-566, MOD:00047 | BUB1p phosphorylated "A BUB1 CDK-consensus sites phosphorylated form in yeast that has phosphorylation at Thr-566. This phosphorylation is essential for deactivating the spindle checkpoint in anaphase and adaptation to prolonged mitotic arrest. UniProtKB:P41695, Thr-566, MOD:00047." [PMID:21298086, PRO:KER] |
acts_upstream_of_or_within | NOT GO:0031577 spindle checkpoint signaling |
PMID:21298086 |
PR:000035421 hBUB1/Phos:10 UniProtKB:O43683-1, Ser-314, MOD:00046 | hBUB1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER] |
acts_upstream_of_or_within | GO:0006281 DNA repair |
PMID:22071147 |
GO:0031577 spindle checkpoint signaling |
PMID:22099307 |
enables | increased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- |
PMID:22071147 |
located_in | GO:0035861 site of double-strand break |
PMID:22071147 |
PR:000035426 frog-BUB1B/Phos:1 UniProtKB:Q8JGT8, Thr-605, MOD:00047 | BUBR1 phosphorylated (frog) | xBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in frog. UniProtKB:Q8JGT8, Thr-605, MOD:00047." [PMID:17998400, PRO:KER] |
acts_upstream_of_or_within | GO:0031577 spindle checkpoint signaling |
PMID:17998400 |
GO:0034501 protein localization to kinetochore |
PMID:17998400 |
GO:0034501 protein localization to kinetochore |
PMID:17998400 |
enables | increased GO:0005515 protein binding with PR:P70032 frog-plk1 |
PMID:17998400 |
PR:000035428 hBUB1B/Phos:2 UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047) | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER] |
acts_upstream_of_or_within | GO:0006974 DNA damage response |
PMID:18440313 |
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- |
PMID:17785528 |
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- |
PMID:17376779; PMID:17785528 |
enables | increased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- |
PMID:17376779 |
increased GO:0005515 protein binding with PR:O43683 BUB1 |
PMID:23079597 |
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A |
PMID:23079597 |
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- |
PMID:23079597 |
located_in | GO:0000776 kinetochore |
PMID:17785528 |
PR:000035430 frog-BUB1B/Phos:2 UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696 "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in frog. This phosphorylation form is observed during mitosis and in conditions of spindle depolymerization (nocodazole). MAD1 is needed for this phosphorylation. UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696." [PMID:12163471, PMID:17998400, PRO:KER] |
enables | increased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- |
PMID:17998400 |
PR:000035432 hBUB1B/Phos:3 UniProtKB:O60566, Thr-608, MOD:00047 | UniProtKB:O60566-1, Thr-608, MOD:00047 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER] |
acts_upstream_of_or_within | decreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- |
PMID:22801780 |
located_in | GO:0000776 kinetochore |
PMID:22801780 |
PR:000035435 hBUB1B/Phos:4 UniProtKB:O60566, Ser-543/Ser-670/Ser-1043, MOD:00046 | UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046 | BUBR1 phosphorylated (human) | hBUBR1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER] |
acts_upstream_of_or_within | increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035373 hBUB1B/PhosRes- |
PMID:19015317; PMID:20016069 |
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- |
PMID:20016069 |
located_in | GO:0000776 kinetochore |
PMID:19015317 |
PR:O08901 mBUB1 Bub1 | BUB1A (mouse) "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of mouse." [OMA:O08901, PMID:19965387, PMID:20057499, PRO:KER] |
acts_upstream_of_or_within | GO:0043069 negative regulation of programmed cell death |
PMID:20057499 |
located_in | GO:0000775 chromosome, centromeric region |
PMID:19965387 |
PR:O43683 hBUB1 BUB1 | BUB1L | BUB1A (human) "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] |
acts_upstream_of_or_within | GO:0007059 chromosome segregation |
PMID:16580887 |
GO:0007062 sister chromatid cohesion |
PMID:16580887 |
GO:0031577 spindle checkpoint signaling |
PMID:15525512 |
GO:0043066 negative regulation of apoptotic process |
PMID:19252416 |
GO:0043069 negative regulation of programmed cell death |
PMID:20057499 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
enables | GO:0004672 protein kinase activity |
PMID:10198256 |
GO:0005515 protein binding with PR:O60566 BUB1B |
PMID:10198256 |
GO:0005515 protein binding with PR:P04637-1 |
PMID:10198256 |
GO:0005515 protein binding with PR:P25054 APC |
PMID:10198256 |
GO:0005515 protein binding with PR:P53350 hPLK1 |
PMID:10198256 |
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) |
PMID:10198256 |
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 |
PMID:10198256 |
GO:0005515 protein binding |
PMID:10198256 |
located_in | GO:0000776 kinetochore |
PMID:20624902 |
GO:0000939 inner kinetochore |
PMID:11792804 |
GO:0000940 outer kinetochore |
PMID:11792804; PMID:16760428 |
PR:O60566 hBUB1B BUB1B | BUBR1 | MAD3L | SSK1 | hBUBR1 | MAD3/BUB1-related protein kinase (human) | mitotic checkpoint kinase MAD3L (human) | protein SSK1 (human) "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566] |
acts_upstream_of_or_within | GO:0006469 negative regulation of protein kinase activity |
PMID:15592459 |
GO:0031577 spindle checkpoint signaling |
PMID:11030144 |
GO:0031647 regulation of protein stability |
PMID:17671183 |
NOT GO:0034501 protein localization to kinetochore |
PMID:16760428 |
GO:0051310 metaphase chromosome alignment |
PMID:12719470; PMID:15592459 |
GO:0051444 negative regulation of ubiquitin-protein transferase activity |
PMID:15525512 |
GO:0051444 negative regulation of ubiquitin-protein transferase activity |
PMID:15525512 |
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore |
PMID:15592459 |
enables | GO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O15350 hTP73 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O15379 HD3 (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O43683 BUB1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O43684 BUB3 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O76070 BCSG1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:O95997 EAP1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P04049 cRaf (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P04637-1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P09874 ADP-ribosyltransferase diphtheria toxin-like 1 (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P25054 APC |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P51587 BRCA2 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:P63010 adaptor protein complex AP-2 subunit beta (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q02224 CENP-E (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q12834 CDC20 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q13042 ANAPC6 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q13257 hMAD2L1 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q13547 HD1 (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q15013 caught by MAD2 protein (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q92769 HD2 (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q92831 histone acetylase PCAF (human) |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q96GD4 AIK2 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q96IF1 AJUBA |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q9H081 hMIS12 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q9H4B4 CNK |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q9NQS7 hINCENP |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q9UJX3 ANAPC7 |
BioGRID:BG-682429 |
GO:0005515 protein binding with PR:Q9UJX5 ANAPC4 |
BioGRID:BG-682429 |
GO:0016301 kinase activity |
PMID:11030144 |
GO:0055105 ubiquitin-protein transferase inhibitor activity |
PMID:15525512 |
GO:0055105 ubiquitin-protein transferase inhibitor activity |
PMID:15525512 |
located_in | GO:0000776 kinetochore |
PMID:12719470; PMID:16760428 |
GO:0000922 spindle pole |
PMID:15190214 |
GO:0000939 inner kinetochore |
PMID:11792804 |
GO:0000940 outer kinetochore |
PMID:11792804 |
GO:0005737 cytoplasm |
PMID:10749118 |
PR:P41695 yBUB1B BUB1 | G7542 | YGR188C "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of yeast." [OMA:P41695, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0006974 DNA damage response |
PMID:15514023 |
enables | GO:0005515 protein binding with PR:000035536 UniProtKB:P53148, Thr-149/Thr-172/Thr-235, MOD:00047 |
PMID:7969164 |
GO:0005515 protein binding with PR:P26449 BUB3 |
PMID:7969164 |
located_in | GO:0000776 kinetochore |
PMID:22521787 |
PR:Q800D4 chick-BUB1B BubR1 "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of chicken." [PMID:17276342, PRO:KER] |
located_in | GO:0000776 kinetochore |
PMID:17276342 |
PR:Q8JGT8 frog-BUB1B xBUBR1 "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of frog." [PMID:12163471, PMID:15241477, PMID:16950116, PRO:KER] |
acts_upstream_of_or_within | GO:0031577 spindle checkpoint signaling |
PMID:12163471 |
GO:0032092 positive regulation of protein binding |
PMID:12163471 |
GO:0032092 positive regulation of protein binding |
PMID:12163471 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0034501 protein localization to kinetochore |
PMID:17709426 |
GO:0051310 metaphase chromosome alignment |
PMID:17709426 |
enables | GO:0004672 protein kinase activity |
PMID:12163471 |
GO:0005515 protein binding with PR:P70039 apc |
PMID:12163471 |
GO:0005515 protein binding with PR:P79935 frog-MAD2L1 |
PMID:12163471 |
GO:0005515 protein binding with PR:Q6DFD4 fizzy |
PMID:12163471 |
GO:0005515 protein binding with PR:Q9YGY3 bub3 |
PMID:12163471 |
GO:0005515 protein binding |
PMID:12163471 |
located_in | GO:0000776 kinetochore |
PMID:12163471; PMID:17709426 |
GO:0005694 chromosome |
PMID:15241477; PMID:16950116 |
PR:Q98UH3 frog-BUB1/var:1
"A mitotic checkpoint serine/threonine-protein kinase BUB1 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q98UH3." [PMID:11231148, PRO:DAN, PRO:KER] |
acts_upstream_of_or_within | GO:0034501 protein localization to kinetochore |
PMID:12163471 |
enables | GO:0005515 protein binding with PR:Q9YGY3 bub3 |
PMID:11231148 |
located_in | GO:0000776 kinetochore |
PMID:11231148; PMID:12163471 |
GO:0005694 chromosome |
PMID:15241477; PMID:16950116 |