Protein Ontology Report - mTLR4 PR:Q9QUK6 - http://purl.obolibrary.org/obo/PR_Q9QUK6

This page represents a class of proteins encompassing all the protein products of the Tlr4 gene in Mus musculus.

Ontology Information
PRO ID	PR:Q9QUK6 Show OBO stanza / PAF / GPI
PRO name	Toll-like receptor 4 (mouse)
Synonyms	PRO-short-label: EXACT: mTLR4 Gene-based: RELATED: Lps | Tlr4 Other: EXACT: CD284 (mouse)
Definition	A Toll-like receptor 4 that is encoded in the genome of mouse. [OMA:Q9QUK6, PRO:DNx]
PRO Category	organism-gene
Parent	PR:000001155 Toll-like receptor 4
Gene Template	MGI:96824 Tlr4
Taxon	NCBITaxon:10090 Mus musculus
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB:Q9QUK6

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

mTLR4 forms found in complexes

mTLR4 Component Complexes PR:000001155 TLR4 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000001155 TLR4 PR:000025784 MYD88:TIRAP:activated TLR4 receptor PR:000001155 TLR4 PR:000036076 activated TLR4 complex PR:000001155 TLR4 PR:000036003 LY96:TLR4 complex PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027204 ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027196 TIRAP:PIP2:activated TLR4 (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036077 activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036005 LY96:TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000037794 MD2:GB4:TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000037476 lipopolysaccharide receptor complex 3 (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse) PR:000027172 mTLR4/iso:1/SigPep-/NGlyco:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:14530355 PR:000037794 MD2:GB4:TLR4 complex (mouse) acts_upstream_of_or_within GO:0034144 negative regulation of toll-like receptor 4 signaling pathway PMID:23471986 enables NOT GO:0001530 lipopolysaccharide binding PMID:23471986 PR:000036005 LY96:TLR4 complex (mouse) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:17803912 PR:000027204 ticam2:activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18222170 located_in GO:0010008 endosome membrane PMID:18222170 PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18222170 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18222170 located_in GO:0010008 endosome membrane PMID:18222170 PR:000036077 activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:23565187 PR:000027196 TIRAP:PIP2:activated TLR4 (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000037476 lipopolysaccharide receptor complex 3 (mouse) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:12196527 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:16306937 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:16306937 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse) acts_upstream_of_or_within GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000027204 ticam2:activated TLR4 complex (mouse) PMID:18222170 PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse) PMID:18222170

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