back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - SMAD4

PR:000000128 - http://purl.obolibrary.org/obo/PR_000000128
Ontology Information
PRO ID PR:000000128 Show OBO stanza / PAF
PRO name smad4
Synonyms
PRO-short-label: EXACT: SMAD4
Gene-based: RELATED: DPC4 | MADH4
Other: EXACT: MAD homolog 4 | SMAD 4 | SMAD family member 4 | deletion target in pancreatic carcinoma 4 | deletion target in pancreatic carcinoma 4 homolog | mothers against DPP homolog 4
Definition A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads. [PMID:10708949, PRO:CNA]
PRO Category gene
Parent PR:000000027 smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 7
modification 5 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

SMAD4 forms found in complexes
SMAD4 Component Complexes
PR:000000366 SMAD4/iso:1 PR:000025969 smad2-smad4 protein complex 3
PR:000000366 SMAD4/iso:1 PR:000025968 smad2-smad4 protein complex 2
PR:000000366 SMAD4/iso:1 PR:000025972 smad2-smad4-ski protein complex 2
PR:000000366 SMAD4/iso:1 PR:000025967 smad2-smad4 protein complex 1
PR:000000366 SMAD4/iso:1 PR:000025970 smad2-smad4 protein complex 4
PR:000000366 SMAD4/iso:1 PR:000025971 smad2-smad4-ski protein complex 1
PR:P97471-1 mSMAD4/iso:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:P97471-1 mSMAD4/iso:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q13485-1
hSMAD4/iso:1
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:14633973
acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:10980615, PMID:15350224, PMID:9346966
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805, PMID:8774881
enables GO:0003700 DNA-binding transcription factor activity PMID:10823886
enables GO:0003712 transcription coregulator activity PMID:10980615
located_in GO:0005634 nucleus PMID:10980615, PMID:15280432
located_in GO:0005737 cytoplasm PMID:15280432
part_of GO:0005667 transcription factor complex PMID:12374795
PR:P97471-1
mSMAD4/iso:1
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:16522160
enables GO:0003700 DNA-binding transcription factor activity PMID:12943993, PMID:14633973, PMID:16522160, PMID:16556916
located_in GO:0005634 nucleus PMID:12543979, PMID:12943993, PMID:16522160
part_of GO:0005667 transcription factor complex PMID:14633973, PMID:9288972, PMID:9702197
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
Lys-519, MOD:01148 		acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enables NOT GO:0046332 SMAD binding PMID:19135894
PR:000025944
smad2-smad4 protein complex 1 (mouse)
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12672795
located_in GO:0005634 nucleus PMID:12672795
PR:000025946
smad2-smad4 protein complex 3 (human)
acts_upstream_of_or_within GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595
located_in GO:0005634 nucleus PMID:12193595
PR:000025947
smad2-smad4 protein complex 4 (human)
acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:11027280
located_in GO:0005737 cytoplasm PMID:11027280
PR:000025952
smad2-smad4-ski protein complex 2 (human)
acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:12732634
located_in GO:0005737 cytoplasm PMID:12732634
PR:000025951
smad2-smad4-ski protein complex 1 (human)
acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:10485843
located_in GO:0005634 nucleus PMID:10485843
PR:000000368
hSMAD4/var:G352R
Gly-352, CHEBI:29952 		associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:12417513
associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000367
hSMAD4/var:E330G
Glu-330, CHEBI:29947 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
PR:000036483
hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enables GO:0003700 DNA-binding transcription factor activity increased relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_in GO:0005634 nucleus PMID:12801888
PR:000000370
hSMAD4/var:G386D
Gly-386, CHEBI:29958 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:15031030
PR:000000371
hSMAD4/var:D493H
Asp-493, CHEBI:29979 		associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:8553070
PR:000000369
hSMAD4/var:R361C
Arg-361, CHEBI:29950 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:9811934
PR:000025933
smad2-smad4 protein complex 1 (human)
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
located_in GO:0005829 cytosol Reactome:REACT_7344
located_in GO:0005654 nucleoplasm Reactome:REACT_7382
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7344
GO:0005654 nucleoplasm PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7382
GO:0005634 nucleus PR:000025944 smad2-smad4 protein complex 1 (mouse)

PMID:12672795
PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
PR:000036483 hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047
PMID:12801888
PR:P97471-1 mSMAD4/iso:1

PMID:12543979, PMID:12943993, PMID:16522160
PR:Q13485-1 hSMAD4/iso:1

PMID:10980615, PMID:15280432
GO:0005737 cytoplasm PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280
PR:000025952 smad2-smad4-ski protein complex 2 (human)

PMID:12732634
PR:Q13485-1 hSMAD4/iso:1

PMID:15280432

top