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Protein Ontology Report - SMAD2

PR:000000364 - http://purl.obolibrary.org/obo/PR_000000364
Ontology Information
PRO ID PR:000000364 Show OBO stanza / PAF
PRO name smad2
Synonyms
PRO-short-label: SMAD2
EXACT: JV18-1; MAD homolog 2; MAD-2; Mad-related protein 2; Mad2; SMAD 2; SMAD family member 2; mothers against DPP homolog 2
RELATED: MADH2; MADR2
Definition A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof. [PMID:9311995]
PRO Category gene
Parent PR:000000066 TGF-beta receptor-regulated smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 2 organism-sequence 9
modification 19 organism-modification 18
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

SMAD2 forms found in complexes
SMAD2 Component Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:000025973 SMAD2/iso:[Long/Short]/UnMod PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000045371
hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
capable_of GO:0005515 protein binding PMID:8980228
located_in GO:0005737 cytoplasm PMID:15280432, PMID:17074053
located_in GO:0005769 early endosome PMID:12356868
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
PR:000025938
hSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
capable_of GO:0003677 DNA binding PMID:14701940, PMID:9873005
capable_of GO:0003700 DNA-binding transcription factor activity PMID:9873005
capable_of GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity PMID:14701940, PMID:9873005
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
PR:Q62432-1
mSMAD2/iso:Long
located_in GO:0005737 cytoplasm PMID:14701940
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747
PR:000000470
hSMAD2/var:R133C
Arg-133, CHEBI:29950
associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209
capable_of NOT GO:0003713 transcription coactivator activity PMID:8752209
has_agent SO:0001606 amino_acid_substitution PMID:8752209
participates_in GO:0007165 signal transduction PMID:8752209
PR:000025933
smad2-smad4 protein complex 1 (human)
located_in GO:0005654 nucleoplasm Reactome:REACT_7382
located_in GO:0005829 cytosol Reactome:REACT_7344
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
PR:000025935
hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
capable_of GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity PMID:12193595
capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:12193595
located_in GO:0005634 nucleus PMID:12193595, PMID:17074053
participates_in GO:0006355 regulation of transcription, DNA-templated PMID:12193595
participates_in GO:0007183 SMAD protein complex assembly PMID:12193595
participates_in GO:0007165 signal transduction PMID:12193595
PR:000025934
hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
capable_of GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity PMID:8980228, PMID:9346966
capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:9311995
capable_of GO:0003713 transcription coactivator activity PMID:9689110
located_in GO:0005634 nucleus PMID:9006934, PMID:9346966
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
participates_in GO:0006355 regulation of transcription, DNA-templated PMID:15690394, PMID:9689110
participates_in GO:0007183 SMAD protein complex assembly PMID:9346966
participates_in GO:0007165 signal transduction PMID:8752209, PMID:8980228, PMID:9346966
PR:000025937
hSMAD2/iso:Long/Phos:4
Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
capable_of NOT GO:0003713 transcription coactivator activity PMID:10197981
located_in GO:0005737 cytoplasm PMID:10197981
PR:000025936
hSMAD2/iso:Long/Phos:3
Ser-240/Ser-465/Ser-467, MOD:00046
capable_of NOT GO:0003713 transcription coactivator activity PMID:11027280
capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:11027280
located_in GO:0005737 cytoplasm PMID:11027280
participates_in GO:0007183 SMAD protein complex assembly PMID:11027280
participates_in GO:0007165 signal transduction PMID:11027280
PR:000000472
hSMAD2/var:P445H
Pro-445, CHEBI:29979
associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209
capable_of NOT GO:0003713 transcription coactivator activity PMID:8752209
has_agent SO:0001606 amino_acid_substitution PMID:8752209
PR:000025951
smad2-smad4-ski protein complex 1 (human)
located_in GO:0005634 nucleus PMID:10485843
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:10485843
PR:000025944
smad2-smad4 protein complex 1 (mouse)
located_in GO:0005634 nucleus PMID:12672795
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12672795
PR:000025946
smad2-smad4 protein complex 3 (human)
located_in GO:0005634 nucleus PMID:12193595
participates_in GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595
PR:000025947
smad2-smad4 protein complex 4 (human)
located_in GO:0005737 cytoplasm PMID:11027280
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:11027280
PR:000025952
smad2-smad4-ski protein complex 2 (human)
located_in GO:0005737 cytoplasm PMID:12732634
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:12732634
PR:000025942
mSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
capable_of GO:0003713 transcription coactivator activity PMID:15282343
capable_of GO:0046332 SMAD binding with PR:P97471 mSMAD4 PMID:11043574
located_in GO:0005634 nucleus PMID:11557747
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
participates_in GO:0007165 signal transduction PMID:11262418
PR:000025943
mSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
capable_of GO:0003700 DNA-binding transcription factor activity PMID:15630024
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024
PR:000000473
hSMAD2/var:D450E
Asp-450, CHEBI:29972
associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209
capable_of NOT GO:0003713 transcription coactivator activity PMID:8752209
has_agent SO:0001606 amino_acid_substitution PMID:8752209
PR:000000471
hSMAD2/var:L440R
Leu-440, CHEBI:29952
associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209
has_agent SO:0001606 amino_acid_substitution PMID:8752209
PR:000036556
hSMAD2/iso:Short/AcPhos:1
Lys-19, MOD:00723|Ser-435/Ser-437, MOD:00046
capable_of GO:0003677 DNA binding PMID:17074756
capable_of GO:0003700 DNA-binding transcription factor activity increased relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
PR:000036555
mSMAD2/iso:Long/PhosUbiq:1
Ser-465/Ser-467, MOD:00046|MOD:01148
capable_of NOT GO:0003713 transcription coactivator activity PMID:15496141
participates_in GO:0007165 signal transduction PMID:15496141
PR:000036554
hSMAD2/iso:Long/AcPhos:1
Lys-19, MOD:00723|Ser-465/Ser-467, MOD:00046
located_in GO:0005634 nucleus PMID:17074756
participates_in GO:0006355 regulation of transcription, DNA-templated PMID:17074756
participates_in GO:0007165 signal transduction PMID:17074756
PR:000000474
hSMAD2/var:5
associated_with_disease_progression DOID:5672 large intestine cancer PMID:8673135
capable_of NOT GO:0003713 transcription coactivator activity PMID:8673135
has_agent SO:0001825 conservative_inframe_deletion PMID:8673135
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007183 SMAD protein complex assembly PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3
Ser-240/Ser-465/Ser-467, MOD:00046
PMID:11027280
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025933 smad2-smad4 protein complex 1 (human)

PMID:8752209, PMID:8980228
PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:8752209, PMID:8980228
PR:000025938 hSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
PMID:9873005
PR:000025942 mSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:11262418
PR:000025943 mSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
PMID:15630024
PR:000025944 smad2-smad4 protein complex 1 (mouse)

PMID:12672795
PR:000036556 hSMAD2/iso:Short/AcPhos:1
Lys-19, MOD:00723|Ser-435/Ser-437, MOD:00046
PMID:17074756
PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:8752209
PR:Q62432-1 mSMAD2/iso:Long

PMID:11557747
GO:0007165 signal transduction PR:000000470 hSMAD2/var:R133C
Arg-133, CHEBI:29950
PMID:8752209
PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:8752209, PMID:8980228, PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3
Ser-240/Ser-465/Ser-467, MOD:00046
PMID:11027280
PR:000025942 mSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:11262418
PR:000036554 hSMAD2/iso:Long/AcPhos:1
Lys-19, MOD:00723|Ser-465/Ser-467, MOD:00046
PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
Ser-465/Ser-467, MOD:00046|MOD:01148
PMID:15496141
GO:0006355 regulation of transcription, DNA-templated PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:15690394, PMID:9689110
PR:000025935 hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
PMID:12193595
PR:000036554 hSMAD2/iso:Long/AcPhos:1
Lys-19, MOD:00723|Ser-465/Ser-467, MOD:00046
PMID:17074756
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280
PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
PR:000025952 smad2-smad4-ski protein complex 2 (human)

PMID:12732634
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7344
GO:0005654 nucleoplasm PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7382
GO:0005634 nucleus PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9006934, PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
PMID:12193595, PMID:17074053
PR:000025942 mSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:11557747
PR:000025944 smad2-smad4 protein complex 1 (mouse)

PMID:12672795
PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
PR:000036554 hSMAD2/iso:Long/AcPhos:1
Lys-19, MOD:00723|Ser-465/Ser-467, MOD:00046
PMID:17074756
GO:0005769 early endosome PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:12356868
GO:0005737 cytoplasm PR:000025936 hSMAD2/iso:Long/Phos:3
Ser-240/Ser-465/Ser-467, MOD:00046
PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
PMID:10197981
PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280
PR:000025952 smad2-smad4-ski protein complex 2 (human)

PMID:12732634
PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:15280432, PMID:17074053
PR:Q62432-1 mSMAD2/iso:Long

PMID:14701940

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